Abstract
Aggregation of 1-hexadecyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide in the presence of diethyl 4-nitrophenyl phosphate was studied using 1H NMR spectroscopy. The quantitative characteristics of the aggregation were determined. The data obtained were used to explain the catalytic effect of micelles on the hydrolysis of the phosphate. It was found that the aggregation properties and biological activity of alkylated mono- and dicationic 1,4-diazabicyclo-[2.2.2]octanes are correlated.
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B. Nikoobakht, M. A. El-Sayed, Chem. Mater., 2003, 15, 1957.
A. V. Shvets, N. V. Kas’yan, E. M. Bezuglaya, G. M. Tel’biz, V. G. Il’in, Teor. Eksp. Khim., 2001, 37, 372 [Theor. Exp. Chem. (Engl. Transl.), 2001, 37].
E. G. Rakov, Usp. Khim., 2001, 70, 934 [Russ. Chem. Rev. (Engl. Transl.), 2001, 70, 827].
S. R. Derkach, G. I. Berestova, T. A. Motyleva, Vestn. Mosk. Gos. Tekh. Univ. [Bulletin of the Moscow State Technical University], 2010, 13, 784 (in Russian).
R. S. Iskanderov, S. N. Aminov, Kh. T. Avezov, Khim. Prir. Soedin., 1998, 648 [Chem. Nat. Compd. (Engl. Transl.), 1998].
L. Ya. Zakharova, A. B. Mirgorodskaya, E. P. Zhiltsova, L. A. Kudryavtseva, A. I. Konovalov, Izv. Akad. Nauk, Ser. Khim., 2004, 1331 [Russ. Chem. Bull., Int. Ed., 2004, 53, 1385].
H. J. Cristau, J. F. Ginieys, E. Torreilles, Bull. Soc. Chim. Fr., 1991, 712.
A. F. Popov, Pure Appl. Chem., 2008, 80, 1381.
A. V. Zakharov, M. A. Voronin, F. G. Valeeva, E. F. Gubanov, in Struktura i dinamika molekulyarnykh sistem [Structures and Dynamics of Molecular Systems], 2003, 10,Part 2, p. 89.
C. A. Bunton, A. A. Kamego, M. J. Minch, J. L. Wright, J. Org. Chem., 1975, 40, 1321.
F. M. Menger, R. A. Persichetti, J. Org. Chem., 1987, 52, 3451.
T. N. Pashirova, E. P. Zhiltsova, R. R. Kashapov, S. S. Lukashenko, A. I. Litvinov, M. K. Kadirov, L. Ya. Zakharova, A. I. Konovalov, Izv. Akad. Nauk, Ser. Khim., 2010, 1699 [Russ. Chem. Bull., Int. Ed., 2010, 59, 1745].
M. Jansson, P. Stilbs, J. Phys. Chem., 1985, 89, 4868.
L. Ya. Zakharova, Yu. R. Kudryashova, N. M. Selivanova, M. A. Voronin, A. I. Ibragimova, S. E. Solovieva, A. T. Gubaidullin, A. I. Litvinov, I. R. Nizameev, M. K. Kadirov, Yu. G. Galyametdinov, I. S. Antipin, A. I. Konovalov, J. Membrane Sci., 2010, 364, 90.
N. K. Gaisin, O. I. Gnezdilov, T. N. Pashirova, E. P. Zhiltsova, S. S. Lukashenko, L. Ya. Zakharova, V. V. Osipova, V. I. Dzhabarov, Yu. G. Galyametdinov, Kolloidn. Zh., 2010, 72, 755 [Colloid J. (Engl. Transl.), 2010, 72].
M. Jansson, P. Stilbs, J. Phys. Chem., 1987, 91, 113.
A. I. Rusanov, Mitselloobrazovanie v rastvorakh poverkhnostno-aktivnykh veshchestv [Micellization in Solutions of Surfactants], Khimiya, St. Petersburg, 1992, 280 pp. (in Russian).
I. V. Berezin, C. Martinec, A. K. Yatsimirskii, Usp. Khim., 1973, 42, 1729 [Russ. Chem. Rev. (Engl. Transl.), 1973, 42, 787].
C. Chachaty, T. Ahlnas, B. Lindstrom, H. Nery, A. M. Tistchenko, J. Colloid Interface Sci., 1988, 122, 406.
Spravochnik khimika [A Chemist’s Handbook], Goskhimizdat, Leningrad—Moscow, 1963, Vol. 1, p. 987 (in Russian).
L. Zakharova, A. Mirgorodskaya, E. Zhiltsova, L. Kudryavtseva, A. Konovalov, in Molecular Encapsulation: Organic Reactions in Constrained Systems, Eds U. H. Brinker, J. L. Mieusset, John Wiley and Sons, Chichester, 2010, p. 397.
D. B. Kudryavtsev, A. R. Panteleeva, A. V. Yurina, S. S. Lukashenko, Yu. P. Khodyrev, R. M. Galiakberov, D. N. Khaziakhmetov, L. A. Kudryavtseva, Neftekhimiya, 2009, 49, 211 [Petrol. Chem. (Engl. Transl.), 2009, 49, 193].
V. M. Bakhir, B. I. Leonov, S. A. Panicheva, V. I. Prilutskii, N. Yu. Shomovskaya, I. I. Strel’nikov, Yu. G. Suchkov, Dezinfektsionnoe delo [Disinfection Science], 2004, 44 (in Russian).
E. P. Tishkova, S. B. Fedorov, L. A. Kudryavtseva, Zh. V. Molodykh, N. L. Kucherova, Sh. M. Yakubov, S. M. Gorbunov, A. M. Zotova, L. V. Teplyakova, A. A. Abramzon, Khim.-Farm. Zh., 1989, 592 [Pharm. Chem. J. (Engl. Transl.), 1989, 418].
N. F. Izmerov, I. V. Sanotskii, K. K. Sidorov, Parametry toksikometrii promyshlennykh yadov pri odnokratnom vvedenii: spravochnik [Toxicometric Parameters of Singly Administered Industrial Poisons: A Handbook], Meditsina, Moscow, 1977, p. 197 (in Russian).
K. Holmberg, B. Jonsson, B. Kronberg, B. Lindman, Surfactants and Polymers in Aqueous Solution, J. Wiley and Sons, Ltd, Chichester, 2002, 562 pp.
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Dedicated to Academician of the Russian Academy of Sciences V. N. Charushin on the occasion of his 60th birthday.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 110—118, January, 2012.
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Zhiltsova, E.P., Pashirova, T.N., Kashapov, R.R. et al. Alkylated 1,4-diazabicyclo[2.2.2]octanes: self-association, catalytic properties, and biological activity. Russ Chem Bull 61, 113–120 (2012). https://doi.org/10.1007/s11172-012-0016-7
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DOI: https://doi.org/10.1007/s11172-012-0016-7