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Synthesis and antibacterial evaluation of several novel tripod pyrazoline with triazine core (TPTC) compounds

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Abstract

A series of new thiocarbamoyl tris-pyrazoline (tripod pyrazoline with triazine core) compounds was obtained by tris-cyclization of chalcone with thiosemicarbazide under basic condition in dry dimethylformamide (DMF) as solvent. Tris-chalcones were prepared by condensation of tris-acetophenone and appropriate aldehydes in basic medium. The newly synthesized compounds were completely identified. The antibacterial activity of the tris-pyrazolines and tris-chalcones was evaluated against Staphylococcus aureus, Micrococcus luteus, Escherichia coli, Pseudomonas aeruginosa, and Bacillus subtilis. Biological data indicated that these compounds are effective against these bacteria.

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Acknowledgments

Partial support of this research by the Research Committee of the University of Guilan is gratefully acknowledged.

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Authors and Affiliations

  1. Department of Organic Chemistry, Faculty of Sciences, University of Guilan, PO Box 41335-1914, Rasht, Iran

    Nosrat O. Mahmoodi & Manouchehr Mamaghani

  2. Department of Organic Chemistry, University Campus 2, University of Guilan, Rasht, Iran

    Masoud Mohammadi Zeydi

  3. Department of Chemistry, Faculty of Sciences, Islamic Azad University, Tonekabon Branch, Tonekabon, 46819-89711, Iran

    Naser Montazeri

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  1. Nosrat O. Mahmoodi
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  2. Masoud Mohammadi Zeydi
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  3. Manouchehr Mamaghani
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  4. Naser Montazeri
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Correspondence to Nosrat O. Mahmoodi.

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Mahmoodi, N.O., Zeydi, M.M., Mamaghani, M. et al. Synthesis and antibacterial evaluation of several novel tripod pyrazoline with triazine core (TPTC) compounds. Res Chem Intermed 43, 2641–2651 (2017). https://doi.org/10.1007/s11164-016-2786-2

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  • DOI: https://doi.org/10.1007/s11164-016-2786-2

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