Abstract
Magnetically separable Fe3O4 nanoparticles were used as an environmental friendly catalyst for the synthesis of mono- and bis-tetrahydro-4H-chromene and mono- and bis-1,4-dihydropyridine derivatives via three-component reactions of aromatic aldehydes and malononitrile with cyclic β-dicarbonyls or cyclic β-enaminoketones respectively. These reactions were carried out in EtOH and at reflux. Fe3O4 nanoparticles can be magnetically separated from the reaction mixture by a magnet and recycled without significant loss of catalytic activity.
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The authors express their great appreciation to the Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, for supporting this investigation.
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Amirheidari, B., Seifi, M. & Abaszadeh, M. Evaluation of magnetically recyclable nano-Fe3O4 as a green catalyst for the synthesis of mono- and bis-tetrahydro-4H-chromene and mono and bis 1,4-dihydropyridine derivatives. Res Chem Intermed 42, 3413–3423 (2016). https://doi.org/10.1007/s11164-015-2220-1
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DOI: https://doi.org/10.1007/s11164-015-2220-1