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Green approach: an efficient synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation

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Abstract

An efficient and rapid procedure for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles has been described by the reaction of α-bromoketones with thiourea, phenylthiourea and selenourea at ambient temperature in aqueous medium under ultrasonic irradiation. Analytically pure products were formed within 10–60 s in excellent yields. The advantageous features of this non-conventional methodology over conventional methods are the operational simplicity, easy handling, yield-enhancing, time-reducing, mild reaction conditions and no by-product production.

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Acknowledgments

We would like to thank the Director, National Institute of Technology, Warangal for providing research facilities. One of the authors R.G. thanks the Ministry of Human Resource Development for financial support.

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Authors and Affiliations

  1. Department of Chemistry, National Institute of Technology, Warangal, 506004, Telangana State, India

    Gondru Ramesh, Banothu Janardhan & Bavantula Rajitha

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  1. Gondru Ramesh
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  2. Banothu Janardhan
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  3. Bavantula Rajitha
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Correspondence to Banothu Janardhan.

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Ramesh, G., Janardhan, B. & Rajitha, B. Green approach: an efficient synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation. Res Chem Intermed 41, 8099–8109 (2015). https://doi.org/10.1007/s11164-014-1879-z

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  • DOI: https://doi.org/10.1007/s11164-014-1879-z

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