Research on Chemical Intermediates

, Volume 40, Issue 4, pp 1715–1725

Synthesis and antimicrobial activity of novel chalcone derivatives

Authors

    • Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of EducationCollege of Chemistry & Materials Science, Northwest University
  • Bingqin Yang
    • Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of EducationCollege of Chemistry & Materials Science, Northwest University
  • Zhao Cheng
    • Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of EducationCollege of Chemistry & Materials Science, Northwest University
  • Pengfei Zhang
    • Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of EducationCollege of Chemistry & Materials Science, Northwest University
  • Meipan Yang
    • Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of EducationCollege of Chemistry & Materials Science, Northwest University
Article

DOI: 10.1007/s11164-013-1076-5

Cite this article as:
Fang, X., Yang, B., Cheng, Z. et al. Res Chem Intermed (2014) 40: 1715. doi:10.1007/s11164-013-1076-5

Abstract

A series of novel 3-[N, N-bis(2-hydroxyethyl)-amino]-chalcone derivatives 3a–3j were synthesized by the aldol condensation of [N, N-bis(2-hydroethyl)-3-amino]-acetophenone 2 with aromatic aldehydes. Their structures were further confirmed by ESI-HRMS, 1H NMR, IR and elemental analysis. X-ray analysis reveals crystal 3b is a monoclinic system with P21/n space group. The antimicrobial activities of the newly synthesized chalcones in vitro were evaluated and the results indicated that most compounds presented moderate to good antimicrobial activities, especially the antifungal capability. Compounds 3a, 3d, 3f and 3g revealed obvious potency against Candida albicans with MIC values of 32 μg/mL, which were better compared with others.

Keywords

Chalcone Synthesis Crystal structure Broth tube dilution method Antimicrobial activity

Supplementary material

11164_2013_1076_MOESM1_ESM.doc (4.8 mb)
Supplementary material 1 (DOC 4923 kb)

Copyright information

© Springer Science+Business Media Dordrecht 2013