Abstract
In the work discussed in this paper, novel β-amino acid derivatives were prepared by Michael addition between 3-substituted-2-propenic acid and hydrazine hydrate. The optimum reaction conditions were determined by analyzing the effects of the ratio of the starting materials, temperature, and reaction time. The conclusions were: reaction temperature 80 °C, reaction time 8 h, n (3-substituted-2-propenic acid)/n (hydrazine hydrate) = 1:15. Products were characterized by measurement of melting point, elemental analysis, and IR and 1H NMR spectroscopy.
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Acknowledgments
The authors are grateful to Shaanxi University of Science and Technology for FTIR spectroscopy, elemental analysis, and 1H NMR and 13C NMR spectroscopic analysis.
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Liu, YT., Feng, L. & Yin, DW. Synthesis and characterization of novel β-amino acid derivatives. Res Chem Intermed 39, 875–880 (2013). https://doi.org/10.1007/s11164-012-0601-2
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DOI: https://doi.org/10.1007/s11164-012-0601-2