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A modified procedure for synthesis of the side chain of ceftazidime-activated thioester

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Abstract

A modified procedure for synthesis of the side chain of ceftazidime-activated thioester has been established. This key intermediate of ceftazidime was obtained by a more eco-friendly process than conventional methods, and the yield was much higher (up to 92.4 %). It was found that different organic bases (triethylamine or pyridine) used in this reaction had different effects. The reaction conditions were also optimized to make the route more competitive and suitable for large-scale industrial production.

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Authors and Affiliations

  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People’s Republic of China

    Lei Li, Guangyuan Wang, Shanshan Wei, Xilong Yan & Ligong Chen

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  1. Lei Li
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  2. Guangyuan Wang
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  3. Shanshan Wei
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  4. Xilong Yan
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  5. Ligong Chen
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Correspondence to Ligong Chen.

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Li, L., Wang, G., Wei, S. et al. A modified procedure for synthesis of the side chain of ceftazidime-activated thioester. Res Chem Intermed 39, 615–620 (2013). https://doi.org/10.1007/s11164-012-0583-0

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  • DOI: https://doi.org/10.1007/s11164-012-0583-0

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