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An environmentally benign protocol: catalyst-free Michael addition of aromatic amines to α,β-unsaturated ketones in glycerol

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Abstract

Glycerol was used as a reaction medium as well as promoter for aza-Michael addition of aromatic amines to electronic deficient α,β-unsaturated ketones. Various aromatic amines can react smoothly with chalcone, 2-cyclohexen-1-one, 2-cyclopenten-1-one, and ethyl vinyl ketone to achieve good to excellent yields in the absence of any catalyst.

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Acknowledgments

This work was supported by the Natural Science Foundation of China (No. 21106090).

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Authors and Affiliations

  1. School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, 318000, People’s Republic of China

    Anguo Ying & Gangfeng Shen

  2. Zhejiang Hisoar Pharmaceutical Co. Ltd., Taizhou, 318000, People’s Republic of China

    Anguo Ying, Qunhui Zhang, Hongmin Li, Weizhong Gong & Mingju He

Authors
  1. Anguo Ying
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  2. Qunhui Zhang
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  3. Hongmin Li
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  4. Gangfeng Shen
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  5. Weizhong Gong
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  6. Mingju He
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Correspondence to Anguo Ying.

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Ying, A., Zhang, Q., Li, H. et al. An environmentally benign protocol: catalyst-free Michael addition of aromatic amines to α,β-unsaturated ketones in glycerol. Res Chem Intermed 39, 517–525 (2013). https://doi.org/10.1007/s11164-012-0575-0

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  • DOI: https://doi.org/10.1007/s11164-012-0575-0

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