Research on Chemical Intermediates

, Volume 38, Issue 2, pp 559-569

First online:

Cytotoxicity, antioxidant, and antimicrobial activities of novel 2-quinolone derivatives derived from coumarin

  • Ahmed A. Al-AmieryAffiliated withBiotechnology Division, Applied Science Department, University of TechnologyDepartment of Chemical and Processing Engineering, Faculty of Engineering and Built Environment, Universiti of Kebangsaan Malaysia Email author 
  • , Redha I. H. Al-BayatiAffiliated withDepartment of Chemistry, College of Sciences, Al-Mustansiriyah University
  • , Kawkab Y. SaourAffiliated withDepartment of Pharmacology, College of Pharmacy, Baghdad University
  • , Mahdi F. RadiAffiliated withDepartment of Chemistry, College of Sciences, Al-Mustansiriyah University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Coumarins are important and useful compounds with diverse pharmacological properties. New coumarin derivatives namely N-aminoquinoline-2-one 1, 1-((4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methyleneamino)quinolin-2(1H)-one 2 and 1,1′-(1E,1′E)-(1,4-phenylenebis(methan-1-yl-1-ylidene))bis(azan-1-yl-1-ylidene)diquinolin-2(1H)-one 3, were synthesized and characterized by UV–Vis, FT-IR, and NMR spectra in addition of elemental analysis. The synthesized compounds (2 and 3) show considerable anticancer activity against HEp-2 cell line. Synthesized compounds (2 and 3) were tested against selected types of microbial organisms and showed significant activities. The free-radical scavenging activity of synthesized compounds (2 and 3) have been determined by their interaction with the stable free-radical 1,1-diphenyl-2-picrilhydrazyl (DPPH) and all the compounds have shown encouraging antioxidant activities.


Anticancer Antioxidant Antimicrobial HEp-2 cell line Quinolone