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Neuroendocrinology of the skin

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Abstract

The skin is considered the mirror of the soul and is affected by neurohormonal triggers, especially stress. Hair follicles, keratinocytes, mast cells, melanocytes, and sebocytes all express sex and stress hormones implicating them in a local “hypothalamic-pituitary-adrenal axis.” In particular, the peptides corticotropin-releasing hormone (CRH) and neurotensin (NT) have synergistic action stimulating mast cells and are uniquely elevated in the serum of patients with skin diseases exacerbated by stress. Addressing the neurohormonal regulation of skin function could lead to new targets for effective treatment of inflammatory skin diseases.

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Authors and Affiliations

  1. Department of Integrative Physiology and Pathobiology, Molecular Immunopharmacology and Drug Discovery Laboratory, Tufts University School of Medicine, 136 Harrison Avenue, Suite J304, Boston, MA, 02111, USA

    Theoharis C. Theoharides, Julia M. Stewart & Alexandra Taracanova

  2. Sackler School of Graduate Biomedical Sciences, Program in Pharmacology and Experimental Therapeutics, Tufts University, Boston, MA, USA

    Theoharis C. Theoharides & Alexandra Taracanova

  3. Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA

    Theoharis C. Theoharides

  4. Department of Graduate Medical Sciences, University of Chieti, Chieti, Italy

    Pio Conti

  5. Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany

    Christos C. Zouboulis

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Theoharides, T.C., Stewart, J.M., Taracanova, A. et al. Neuroendocrinology of the skin. Rev Endocr Metab Disord 17, 287–294 (2016). https://doi.org/10.1007/s11154-016-9369-9

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