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Study on the preparation of l-α-glycerophosphocholine catalyzed by low boiling point organic amines

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Abstract

The transesterification of phosphatidylcholine (PC for short) catalyzed by 12 kinds of low boiling point amines was examined under mild conditions to prepare l-α-glycerophosphocholine (GPC for short). The amines were confirmed as effective catalysts for GPC production, and the process using this kind of catalyst would be much simpler, since the recovery of the catalysts can be combined with the recovery of methanol by distillation. Three kinds of amines with boiling points lower than 50 °C and higher activities were applied to produce GPC, the yield of GPC could reach 90 % with a catalyst content of 2.4 %. The mechanism of the methanolysis catalyzed by the primary amine was proposed and the experimental data fit the equation model well. Isopropylamine showed better activity with higher yield of GPC and lower activation energy than others. Gas Chromatography and 1H NMR were used to analyze the product, which indicated that the product had high purity and there was no reaction between the catalyst and other materials. The catalyst could get similar effect to the fresh after repeated uses.

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Acknowledgments

Authors are grateful for the supports from the Science and Technique Foundation of Shannxi (No. 2004K08-C24) and the Industrialization foundation of Shaanxi Province Education Department (No. 04JC05).

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Authors and Affiliations

  1. School of Chemical Engineering, Northwest University, Xi’an, 710069, China

    Hongya Li, Xiaoli Zhang, Jiebing Zhang, Tiantian Zhang & Binxia Zhao

  2. School of Chemistry and Chemical Engineering, Yulin University, Yulin, 719000, China

    Hongya Li

  3. Shaanxi Applied Physics and Chemistry Research Institute, Xi’an, 710061, China

    Weili Bai

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  1. Hongya Li
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  2. Xiaoli Zhang
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  3. Weili Bai
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  4. Jiebing Zhang
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  5. Tiantian Zhang
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  6. Binxia Zhao
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Correspondence to Xiaoli Zhang.

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Li, H., Zhang, X., Bai, W. et al. Study on the preparation of l-α-glycerophosphocholine catalyzed by low boiling point organic amines. Reac Kinet Mech Cat 108, 305–316 (2013). https://doi.org/10.1007/s11144-012-0509-2

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  • DOI: https://doi.org/10.1007/s11144-012-0509-2

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