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Are the EQ-5D-3L and the ICECAP-O responsive among older adults with impaired mobility? Evidence from the Vancouver Falls Prevention Cohort Study

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Abstract

Purpose

Preference-based generic measures are gaining increased use in mobility research to assess health-related quality of life and wellbeing. Hence, we examined the responsiveness of these two measures among individuals at risk of mobility impairment among adults aged ≥70 years.

Methods

We conducted a 12-month prospective cohort study of community-dwelling older adults (n = 288 to n = 341 depending on analysis) who were seen at the Vancouver Falls Prevention Clinic who had a history of at least one fall in the previous 12 months. We compared the responsiveness of the EuroQol-5 Domain-3 Level (EQ-5D-3L) and the index of capability for older adults (ICECAP-O) by examining changes in these measures over time (i.e., over 6 and 12 months) and by examining whether their changes varied as a function of having experienced 2 or more falls over 6 and 12 months.

Results

Only the ICECAP-O showed a significant change over time from baseline through 12 months; however, neither measure showed change that exceeded the standard error of the mean. Both measures were responsive to falls that occurred during the first 6 months of the study (p < .05). These effects appeared to be amplified among individuals identified as having mild cognitive impairment (MCI) at baseline (p < .01). Additionally, the EQ-5D-3L was responsive among fallers who did not have MCI as well as individuals with MCI who did not fall (p < .05).

Conclusion

This study provides initial evidence suggesting that the EQ-5D-3L is generally more responsive, particularly during the first 6 months of falls tracking among older adults at risk of future mobility impairment.

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Acknowledgements

We thank the Vancouver Falls Prevention Cohort study participants. The Canadian Institute for Health Research Emerging Team Grant (CIHR, MOB-93373 to KMK and TLA) provided funding for this study. TLA is a Canada Research Chair in Physical Activity, Mobility, and Cognitive Neuroscience, a Michael Smith Foundation for Health Research (MSFHR) Scholar, a Canadian Institutes of Health Research (CIHR) New Investigator, and a Heart and Stroke Foundation of Canada’s Henry JM Barnett’s Scholarship recipient. JCD and JRB were funded by a CIHR and MSFHR Postdoctoral Fellowship at the onset of this study. CLS is a CIHR Doctoral Trainee. These funding agencies did not play a role in study design. We obtained approval for the Vancouver Falls Prevention Clinic Cohort study from UBC Clinical Ethics Review Board.

Author’s contribution

TLA was principal investigator for the Vancouver Falls Prevention Clinic Cohort study. TLA and JCD were responsible for study concept and design, acquisition of data, data analysis and interpretation, writing and reviewing of the manuscript. JRB and JCD were responsible for data analysis. JCD, TLA, JRB, LD, CLH, KMK, WC, WC and WC drafted and revised the manuscript. JCD, TLA, JD and LD acquired and interpreted the data.

Funding

This study was funded by the Canadian Institute for Health Research Emerging Team Grant (CIHR grant number, MOB-93373 to KMK, TLA).

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Authors and Affiliations

  1. Center for Hip Health and Mobility, Robert HN Ho Building 2635 Laurel St, Vancouver, BC, V5Z 1M9, Canada

    Jennifer C. Davis, John R. Best, Chun Liang Hsu, Wency Chan, Winnie Cheung & Teresa Liu-Ambrose

  2. Aging, Mobility, and Cognitive Neuroscience Lab, Department of Physical Therapy, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada

    Karim M. Khan & Teresa Liu-Ambrose

  3. Department of Medicine, University of British Columbia, Vancouver, BC, Canada

    Karim M. Khan & Teresa Liu-Ambrose

  4. Djavad Mowafaghian Centre for Brain Health, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada

    Larry Dian & Teresa Liu-Ambrose

Authors
  1. Jennifer C. Davis
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  8. Teresa Liu-Ambrose
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Corresponding author

Correspondence to Teresa Liu-Ambrose.

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Conflict of interest

Jennifer C. Davis, John R Best, Larry Dian, Karim M. Khan, Chun Liang Hsu, Wency Chan, Winnie Cheung, Teresa Liu-Ambrose declares that they have no conflict of interest.

Ethical approval

Ethical approval was obtained from the Vancouver Coastal Health Research Institute and the University of British Columbia’s Clinical Research Ethics Board (H09-02370).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Davis, J.C., Best, J.R., Dian, L. et al. Are the EQ-5D-3L and the ICECAP-O responsive among older adults with impaired mobility? Evidence from the Vancouver Falls Prevention Cohort Study. Qual Life Res 26, 737–747 (2017). https://doi.org/10.1007/s11136-016-1487-z

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