Quality of Life Research

, Volume 21, Issue 4, pp 613–623

Changes in drug use are associated with health-related quality of life improvements among methadone maintenance patients with HIV/AIDS

Authors

    • 1-42, Department of Public Health Sciences, School of Public HealthUniversity of Alberta
    • Institute for Preventive Medicine and Public HealthHanoi Medical University
  • Arto Ohinmaa
    • 1-42, Department of Public Health Sciences, School of Public HealthUniversity of Alberta
    • Institute of Health Economics
  • Anh Thuy Duong
    • Administration of HIV/AIDS ControlMinistry of Health
  • Nhan Thi Do
    • Administration of HIV/AIDS ControlMinistry of Health
  • Long Thanh Nguyen
    • Administration of HIV/AIDS ControlMinistry of Health
  • Quoc Cuong Nguyen
    • Family Health International
  • Steve Mills
    • Family Health International
  • Philip Jacobs
    • Institute of Health Economics
    • Faculty of Medicine and DentistryUniversity of Alberta
  • Stan Houston
    • 1-42, Department of Public Health Sciences, School of Public HealthUniversity of Alberta
    • Faculty of Medicine and DentistryUniversity of Alberta
Article

DOI: 10.1007/s11136-011-9963-y

Cite this article as:
Tran, B.X., Ohinmaa, A., Duong, A.T. et al. Qual Life Res (2012) 21: 613. doi:10.1007/s11136-011-9963-y

Abstract

Purpose

This longitudinal study assessed the changes in drug use patterns and health-related quality of life (HRQL) among HIV-positive drug users in the first methadone maintenance treatment (MMT) cohort in Vietnam.

Methods

A secondary analysis was conducted on 370 HIV-positive drug users (age: mean ± SD: 29.5 ± 5.9 years; 95.7% men). Modified WHOQOL-BREF, self-report, and opioid confirmatory urine tests were used to assess HRQL and drug use behaviours at baseline, 3, 6, and 9 months. Generalized estimating equations (GEE) models were constructed to adjust for intra-individual correlations.

Results

MMT response rate after 9 months was 89.9%. Rates of positive heroin urine tests rapidly decreased at the first trimester (18.1%) and then stabilized during the next 2 trimesters (11.8 and 14.4%). Among patients with continued drug use, frequency of use decreased from 3.4 to 0.7 time/day. Improvements in HRQL were large over the course of the study and highest in the psychological domain. Adjusting for propensity score in GEE models, ongoing heroin use during MMT resulted in large decrements in all HRQL domains.

Conclusions

MMT improved the outcomes of treatment for drug users in ways that might facilitate success of antiretroviral therapy. Integrating MMT to HIV care and treatment services could be beneficial in injection-driven HIV epidemics in resource-scare settings.

Keywords

Quality of lifeHIVDrug useMethadoneVietnamWHOQOL-BREF

Copyright information

© Springer Science+Business Media B.V. 2011