Skip to main content
SpringerLink
Log in

A Study of Glycemic Response to Corinthian Raisins in Healthy Subjects and in Type 2 Diabetes Mellitus Patients

  • Original Paper
  • Published:
Plant Foods for Human Nutrition Aims and scope Submit manuscript

Abstract

This study was designed to evaluate the metabolic response to Corinthian raisins in healthy and in patients with type 2 diabetes mellitus. Healthy subjects (n = 15) and diabetic patients (n = 15) received 74 g raisins or 50 g glucose as reference food. Blood samples were collected at time 0 (before the consumption) and 30, 60, 90, 120, 150 and 180 min after raisin or glucose consumption. There was no significant difference in baseline glucose and insulin between raisins and reference in both groups. The difference at glucose peaks between raisins and reference was significant in healthy and in diabetics. Glycemic and insulinemic responses were decreased after raisin consumption compared to reference. An estimate of the glycemic index would be 66.3 ± 3.4.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

Abbreviations

AUC:

Area under the curve

BMI:

Body mass index

CR:

Corinthian raisins

GI:

Glycemic index

GL:

Glycemic load

HbA1c:

Glycated hemoglobin

II:

Insulin index

T2DM:

Type 2 diabetes mellitus

References

  1. Barclay AW, Petocz P, McMillan-Price J, Flood VM, Prvan T, Mitchell P, Brand-Miller JC (2008) Glycemic index, glycemic load, and chronic disease risk-a meta-analysis of observational studies. Am J Clin Nutr 87:627–637

    CAS  Google Scholar 

  2. Menezes EW, Dan MC, Cardenette GH, Goñi I, Bello-Pérez LA, Lajolo FM (2010) In vitro colonic fermentation and glycemic response of different kinds of unripe banana flour. Plant Foods Hum Nutr 65:379–385

    Article  CAS  Google Scholar 

  3. Rendell M, Vanderhoof J, Venn M, Shehan MA, Arndt E, Rao CS, Gill G, Newman RK, Newman CW (2005) Effect of a barley breakfast cereal on blood glucose and insulin response in normal and diabetic patients. Plant Foods Hum Nutr 60:63–67

    Article  CAS  Google Scholar 

  4. Chiou A, Karathanos VT, Mylona A, Salta FN, Preventi F, Andrikopoulos NK (2007) Currants (Vitis vinifera L.) content of simple phenolics and antioxidant activity. Food Chem 102:516–522

    Google Scholar 

  5. Andrade-Cetto A, Wiedenfeld H (2001) Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J Ethnopharmacol 78:145–149

    Google Scholar 

  6. American Diabetes Association (2010) Diagnosis and classification of diabetes mellitus. Diabetes Care 33:S62–S69

    Google Scholar 

  7. Pagana KD, Pagana TJ (2010) Mosby’s manual of diagnostic and laboratory tests. In: Pagana KD, Pagana TJ (eds) Blood Studies, 4th edn. Elsevier, St Louis, pp 270–275

    Google Scholar 

  8. Wolever TMS, Jenkins DJA, Jenkins AL, Josse RG (1991) The glycemic index: methodology and clinical implications. Am J Clin Nutr 54:846–854

    CAS  Google Scholar 

  9. Webster SGP, Leeming JT (1975) Assessment of small bowel function in the elderly using a modified xylose tolerance test. Gut 16:109–113

    Article  CAS  Google Scholar 

  10. Levitan EB, Cook NR, Stampfer MJ, Ridker PM, Rexrode KM, Buring JE, Manson JE, Liu S (2008) Dietary glycemic index, dietary glycemic load, blood lipids, and C-reactive protein. Metabolism 57:437–443

    Article  CAS  Google Scholar 

  11. Jiang R, Jacobs DR, Mayer-Davis E, Szklo M, Herrington D, Jenny NS, Kronmal R, Barr RG (2006) Nut and seed consumption and inflammatory markers in the multi-ethnic study of atherosclerosis. Am J Epidemiol 163:222–231

    Article  Google Scholar 

  12. Jenkins DJ, Srichaikul K, Kendall CW, Sievenpiper JL, Abdulnour S, Mirrahimi A, Meneses C, Nishi S, He X, Lee S et al (2011) The relation of low glycaemic index fruit consumption to glycaemic control and risk factors for coronary heart disease in type 2 diabetes. Diabetologia 54:271–279

    Article  CAS  Google Scholar 

  13. Matsui T, Ebuchi S, Kobayashi M, Fukui K, Sugita K, Terahara N, Matsumoto K (2002) Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the alpha-glucosidase inhibitory action. J Agric Food Chem 50:7244–7248

    Google Scholar 

  14. Liu IM, Tzeng TF, Liou SS, Lan TW (2007) Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats. Life Sci 81:1479–1488

    Article  CAS  Google Scholar 

  15. Wursch P, Pi-Sunyer FX (2002) The role of viscous soluble fiber in the metabolic control of diabetes: a review with special emphasis on cereals rich in beta-glucan. Diabetes Care 20:1774–1780

    Article  Google Scholar 

  16. Wolever TMS (2000) Dietary carbohydrates and insulin action in humans. Br J Nutr 83:S97–S102

    Article  CAS  Google Scholar 

  17. Jenkins DJA, Axelsen M, Kendall CWC, Augustin LSA, Vuksan V, Smith U (2000) Dietary fibre, lente carbohydrates and the insulin-resistant disease. Br J Nutr 83:S157–S163

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The study was funded by the Corinthian Raisins Cooperative SKOS A.S.E. within the framework of NSRF 2007-2013 Programme for Development (EU Regional Development Fund), Greek Ministry of Education and Religious Affairs, Cuture & Sports. Corinthian Raisins were kindly donated by the Agricultural Cooperatives Union - Aeghion, Greece (P.E.S. Union).

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Science of Dietetics–Nutrition, Harokopio University, 70 El. Venizelou str. Kallithea, 17 671, Athens, Greece

    Panagiotis T. Kanellos, Andriana C. Kaliora & Vaios T. Karathanos

  2. 1st Department of Propaedeutic and Internal Medicine, Laiko General Hospital, National and Kapodistrian University, Medical School, 17 Ag. Thoma Street, 115 27, Athens, Greece

    Christos Liaskos & Nikolaos K. Tentolouris

  3. Laboratory of Experimental Surgery and Surgical Research N.S. Christeas, National and Kapodistrian University, Medical School, 17 Ag. Thoma Street, 115 27, Athens, Greece

    Despina Perrea

Authors
  1. Panagiotis T. Kanellos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andriana C. Kaliora
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Christos Liaskos
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Nikolaos K. Tentolouris
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Despina Perrea
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Vaios T. Karathanos
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Andriana C. Kaliora.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kanellos, P.T., Kaliora, A.C., Liaskos, C. et al. A Study of Glycemic Response to Corinthian Raisins in Healthy Subjects and in Type 2 Diabetes Mellitus Patients. Plant Foods Hum Nutr 68, 145–148 (2013). https://doi.org/10.1007/s11130-013-0348-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11130-013-0348-y

Keywords

Search

Navigation