Original Paper

Plant Foods for Human Nutrition

, Volume 64, Issue 4, pp 231-237

Improved Antioxidant and Anti-inflammatory Potential in Mice Consuming Sour Cherry Juice (Prunus Cerasus cv. Maraska)

  • Ana ŠarićAffiliated withDivision of Molecular Medicine, Rudjer Bošković Institute
  • , Sandra SobočanecAffiliated withDivision of Molecular Medicine, Rudjer Bošković Institute
  • , Tihomir BalogAffiliated withDivision of Molecular Medicine, Rudjer Bošković Institute Email author 
  • , Borka KušićAffiliated withDivision of Molecular Medicine, Rudjer Bošković Institute
  • , Višnja ŠverkoAffiliated withDivision of Molecular Medicine, Rudjer Bošković Institute
  • , Verica Dragović-UzelacAffiliated withFaculty of Food Technology and Biotechnology
  • , Branka LevajAffiliated withFaculty of Food Technology and Biotechnology
  • , Zrinka ČosićAffiliated withMaraska d.d.
  • , Željka Mačak ŠafrankoAffiliated withDivision of Molecular Medicine, Rudjer Bošković Institute
    • , Tatjana MarottiAffiliated withDivision of Molecular Medicine, Rudjer Bošković Institute

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Abstract

The present investigation tested the in vivo antioxidant efficacy (superoxide dismutase, SOD; catalase, CAT; glutathione peroxidase; Gpx), lipid peroxidation (LPO) and anti-inflammatory properties (cyclooxygenase-2; COX-2) of sour cherry juices obtained from an autochthonous cultivar (Prunus cerasus cv. Maraska) that is grown in coastal parts of Croatia. Antioxidant potential was tested in mouse tissue (blood, liver, and brain), LPO (liver, brain) and anti-inflammatory properties in glycogen elicited macrophages. Additionally, the concentration of cyanidin-3-glucoside, cyanidin-3-rutinoside, pelargonidin-3-glucoside, pelargonidin-3-rutinoside and total anthocyanins present in Prunus cerasus cv. Maraska cherry juice was determined. Mice were randomly divided into a control group (fed with commercial food pellets) and 2 experimental groups (fed with commercial food pellets with 10% or 50% of cherry juice added). Among the anthocyanins, the cyanidin-3-glucoside was present in the highest concentration. These results show antioxidant action of cherry juice through increased SOD (liver, blood) and Gpx (liver) activity and decreased LPO concentration. The study highlights cherry juice as a potent COX-2 inhibitor and antioxidant in the liver and blood of mice, but not in the brain. Thus, according to our study, Prunus cerasus cv. Maraska cherry juice might potentially be used as an antioxidant and anti-inflammatory product with beneficial health-promoting properties.

Keywords

Cherry juice Antioxidant Lipid peroxidation Anti-inflammatory Cyanidin 3-glucoside Cyclooxygenase-2 (COX-2) activity