Abstract
Several studies on cognition in bipolar disorder (BD) have been developed on the last decade. Neuropsychological evaluation of attention in BD patients is fundamental since alterations in attention affect other cognitive functions. Evaluate if performance of BD patients in attention tests varies according to each phase of the disease and verify if there are differences in attention when comparing BD patients with normal controls. The study included 101 BD patients, with ages between 18 and 65 years, being 52 euthymic, 22 manic and 27 depressive, besides 30 normal controls. All subjects were evaluated though Hamilton Depression Scale, Young Mania Rating Scale and Global Assessment of Functioning, bipolar version (CGI-BP). Attention was evaluated through a neuropsychological battery. Normal controls had a better performance in selective attention tests than BD patients. No differences were found among manic, depressive and euthymic phases. Attention is markedly impaired in BD. Nevertheless, the results of this study do not imply that the severity of the attention deficit in BD patients varies according to decease phase.
Similar content being viewed by others
References
American Psychiatric Association: DSM-IV: Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Artmed, Porto Alegre, 2002.
Bonnín CM, Sánchez-Moreno J, Martínez-Arán A, Solé B, Reinares M, Rosa AR, Goikolea JM, Benabarre A, Ayuso-Mateos JL, Ferrer M, Vieta E, Torrent C: Subthreshold symptoms in bipolar disorder: Impact on neurocognition, quality of life and disability. Journal of Affective Disorders 136(3):650–659, 2012.
Burdick KE, Gunawardane N, Goldberg JF, Halperin JM, Garno JL, Malhotra AK: Attention and psychomotor functioning in bipolar depression. Psychiatric Research 166(2–3):192–200, 2009.
Camelo EVM, Velasques B, Ribeiro P, Netto T, Cheniaux E: Impairment in bipolar disorder: A systematic review. Psychology and Neuroscience 6:299–309, 2013.
Clark L, Goodwin GM: State- and trait-related deficits in sustained attention in bipolar disorder. European Archives of Psychiatry and Clinical Neuroscience 254(2):61–68, 2004.
Critério de Classificação Econômica Brasil (CCEB, 2008) Associação Brasileira de Empresas de Pesquisa (ABEP) www.abep.org. Accessed 12 March 2015.
Deckersbach T, Nierenberg AA, Kessler R, Lund HG, Ametrano RM, Sachs G, Rauch SL, Dougherty D: RESEARCH: Cognitive rehabilitation for bipolar disorder: An open trial for employed patients with residual depressive symptoms. CNS Neuroscience & Therapeutics 16(5):298–307, 2010.
Del-Ben CM, Vilela JAA, de S Crippa JA, Hallak JEC, Labate CM, Zuardi AW: Confiabilidade de ‘‘Entrevista Clınica Estruturada para o DSM-IV–Versão Clınica” traduzida para o português/Reliability of the Structured Clinical Interview for DSM-IV–Revista Brasileira de Psiquiatria 23:156–159, 2010.
Fonseca RP, Parente MAMP, Côté H, Ska B, Joanette Y: Bateria Montreal de Avaliação da Comunicação—Bateria MAC. Pró-Fono, São Paulo, 2008.
Frantom LV, Allen DN, Cross CL: Neurocognitive endophenotypes for bipolar disorder. Bipolar Disorder 10(3):387–399, 2008.
Gualtieri CT, Morgan DW: The frequency of cognitive impairment in patients with anxiety, depression, and bipolar disorder: An unaccounted source of variance in clinical trials. Journal of Clinical Psychiatry 69(7):1122–1130, 2008.
Gaudino EA, Geisler MW, Squires NK: Construct validity in the Trail Making Test: What makes Part B harder? Journal of Clinical and Experimental Neuropsychology 17(4):529–535, 1995.
Goodwin FK, Jamison KR, Ghaemi SN: Manic-depressive illness: Bipolar disorders and recurrent depression, 2nd edn. Oxford University Press, New York, 2007.
Hamilton M: A rating scale for depression. The Journal of Neurology, Neurosurgery, and Psychiatry 23:56–62, 1960.
Levine B, Turner GR, Stuss D: Rehabilitation of frontal lobe functions. In: Stuss DT, Winocur G, Robertson IH (Eds.): Cognitive neurorehabilitation: Evidence and application, 2nd edn. Cambridge University Press, Cambridge, UK, pp. 464–486, 2008.
Lewandowski KE, Cohen BM, Keshavan MS, Ongür D: Relationship of neurocognitive deficits to diagnosis and symptoms across affective and non-affective psychoses. Schizophrenia Research 133(1–3):212–217, 2011.
Mahlberg R, Adli M, Bschor T, Kienast T: Age effects on trail making test during acute depressive and manic episode. International Journal of Neuroscience 118(9):1347-56, 2008.
Maalouf FT, Klein C, Clark L, Sahakian BJ, Labarbara EJ, Versace A, Hassel S, Almeida JR, Phillips ML: Impaired sustained attention and executive dysfunction: Bipolar disorder versus depression-specific markers of affective disorders. Neuropsychologia 48(6):1862–1868, 2010.
Martinez-Aran A, Vieta E, Reinares M, Colom F, Torrent C, Sanchez-Moreno J: Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder. American Journal of Psychiatry 161(2):262–270, 2004.
Martinez-Aran A, Scott J, Colom F, Torrent C, Tabares-Seisdedos R, Daban C, Leboyer M, Henry C, Goodwin GM, Gonzalez-Pinto A, Cruz N, Sanchez-Moreno J, Vieta E: Treatment nonadherence and neurocognitive impairment in bipolar disorder. Journal of Clinical Psychiatry 70(7):1017–1023, 2009.
Meusel LA, Hall GB, Fougere P, McKinnon MC, MacQueen GM: Neural correlates of cognitive remediation in patients with mood disorders. Psychiatry Research 214(2):142–52, 2013.
Nascimento E, Figueiredo VLM: WISC-III and WAIS-III: Alterations in the current american original versions of the adaptations for use in Brazil. Psicologia Reflexão e Crítica 15(3):603–612, 2002.
Field A: Discovering statistics with SPSS, 4th edn. Sage, New York, 2013.
Olvet DM, Burdick KE, Cornblatt BA: Assessing the potential to use neurocognition to predict who is at risk for developing bipolar disorder: A review of the literature. Cognitive Neuropsychiatry 18(1–2):129–145, 2013.
Pattanayak RD, Sagar R, Mehta M: Neuropsychological performance in euthymic Indian patients with bipolar disorder type I: Correlation between quality of life and global functioning. Psychiatry and Clinical Neurosciences 66(7):553–563, 2012.
Pompei F, Jigar J, Roberto T, Paolo G, Katya R, Kumari V, Frangou S: Familial and disease specific abnormalities in the neural correlates of the Stroop Task in Bipolar Disorder. Neuroimage 56(3):1677–1684, 2011.
Rocca CC, Lafer B: Neuropsychological disturbances in bipolar disorder. Revista Brasileira de Psiquiatria 28(3):226–237, 2006.
Soeiro-de-Souza MG, Post RM, de Sousa ML, Missio G, do Prado CM, Gattaz WF, Moreno RA, Machado-Vieira R: Does BDNF genotype influence creative output in bipolar I manic patients? Journal of Affective Disorders 139(2):181–186, 2012.
Spearing MK, Post RM, Leverich GS, Brandt D, Nolen W: Modification of the Clinical Global Impressions (CGI) Scale for use in bipolar illness (BP): The CGI-BP. Psychiatry Research 73(3):159–171, 1997.
Stroop J: Studies of interference in serial verbal reactions. Journal of Experimental Psychology: General 18(6):643–662, 1935.
Torrent C, Martinez-Arán A, Daban C, Amann B, Balanzá-Martínez V, del Mar Bonnín Cruz N, Franco C, Tabares-Seisdedos R, Vieta E: Effects of atypical antipsychotics on neurocognition in euthymic bipolar patients. Comprehensive Psychiatry 52(6):613–622, 2011.
Trivedi JK, Goel D, Sharma S, Singh PK, Tandon, R: Cognitive functions in stable schizophrenia & euthymic state of bipolar disorder. Indian Journal of Medicine Research 126(5):433–439, 2008.
Van der Werf-Eldering MJ, Burger H, Jabben N, Holthausen EA, Aleman A, Nolen WA: Is the lack of association between cognitive complaints and objective cognitive functioning in patients with bipolar disorder moderated by depressive symptoms? Journal of Affective Disorders 130(1–2):306–311, 2011.
Van Gorp WG, Altshuler L, Theberge DC, Wilkins J, Dixon W: Cognitive impairment in euthymic bipolar patients with and without prior alcohol dependence. Archives of General Psychiatry 55(1):41–46, 1998.
Vieta E: Avanços no transtorno bipolar. Conectfarma, Recife, 2012.
Wechsler D: WAIS-III: Escala de Inteligência Wechsler para Adultos: Manual técnico (M. C. Vilhena, Trad.). Casa do Psicólogo, São Paulo, 2005.
Young RC, Biggs JT, Ziegler VE, Meyer DA: A rating scale for mania: Reliability, validity and sensitivity. The British Journal of Psychiatry 133:429–445, 1978.
Conflict of interest
Evelyn V. M. Camelo, Daniel Mograbi, Rafael de Assis da Silva, Jaqueline Bifano, Mayra Wainstok, Luciana Angélica Silva Silveira, Tânia Netto, Cristina M. T. Santana, and Elie Cheniaux declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Ethical approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Rights and permissions
About this article
Cite this article
Camelo, E.V.M., Mograbi, D., de Assis da Silva, R. et al. Performance of Bipolar Disorder Patients in Attention Testing: Comparison with Normal Controls and Among Manic, Depressive, and Euthymic Phases. Psychiatr Q 88, 55–63 (2017). https://doi.org/10.1007/s11126-016-9430-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11126-016-9430-6