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Enrichment of cereal grains with zinc: Agronomic or genetic biofortification?

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Abstract

Zinc deficiency is a well-documented problem in food crops, causing decreased crop yields and nutritional quality. Generally, the regions in the world with Zn-deficient soils are also characterized by widespread Zn deficiency in humans. Recent estimates indicate that nearly half of world population suffers from Zn deficiency. Cereal crops play an important role in satisfying daily calorie intake in developing world, but they are inherently very low in Zn concentrations in grain, particularly when grown on Zn-deficient soils. The reliance on cereal-based diets may induce Zn deficiency-related health problems in humans, such as impairments in physical development, immune system and brain function. Among the strategies being discussed as major solution to Zn deficiency, plant breeding strategy (e.g., genetic biofortification) appears to be a most sustainable and cost-effective approach useful in improving Zn concentrations in grain. The breeding approach is, however, a long-term process requiring a substantial effort and resources. A successful breeding program for biofortifying food crops with Zn is very much dependent on the size of plant-available Zn pools in soil. In most parts of the cereal-growing areas, soils have, however, a variety of chemical and physical problems that significantly reduce availability of Zn to plant roots. Hence, the genetic capacity of the newly developed (biofortified) cultivars to absorb sufficient amount of Zn from soil and accumulate it in the grain may not be expressed to the full extent. It is, therefore, essential to have a short-term approach to improve Zn concentration in cereal grains. Application of Zn fertilizers or Zn-enriched NPK fertilizers (e.g., agronomic biofortification) offers a rapid solution to the problem, and represents useful complementary approach to on-going breeding programs. There is increasing evidence showing that foliar or combined soil+foliar application of Zn fertilizers under field conditions are highly effective and very practical way to maximize uptake and accumulation of Zn in whole wheat grain, raising concentration up to 60 mg Zn kg−1. Zinc-enriched grains are also of great importance for crop productivity resulting in better seedling vigor, denser stands and higher stress tolerance on potentially Zn-deficient soils. Agronomic biofortification strategy appears to be essential in keeping sufficient amount of available Zn in soil solution and maintaining adequate Zn transport to the seeds during reproductive growth stage. Finally, agronomic biofortification is required for optimizing and ensuring the success of genetic biofortification of cereal grains with Zn. In case of greater bioavailability of the grain Zn derived from foliar applications than from soil, agronomic biofortification would be a very attractive and useful strategy in solving Zn deficiency-related health problems globally and effectively.

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References

  • Abbate PE, Andrade FH, Lázaro L, Bariffi JH, Berardocco HG, Inza VH, Marturano F (1998) Grain yield increase in recent Argentine wheat cultivars. Crop Sci 38:1203–1209

    Article  Google Scholar 

  • Ajouri A, Asgedom H, Becker M (2004) Seed priming enhances germination and seedling growth of barley under conditions of P and Zn deficiency. J Plant Nutr Soil Sci 167:630–636

    Article  Google Scholar 

  • Alloway BJ (2004) Zinc in soils and crop nutrition. IZA Publications. International Zinc Association, Brussels, pp 1–116

    Google Scholar 

  • Arthur JR (2003) Selenium supplementation: does soil supplementation help and why? Proc Nutr Soc 62:393–397

    Article  PubMed  CAS  Google Scholar 

  • Aspila P (2005) History of selenium supplemented fertilization in Finland. In: Eurola M (ed) Proceedings twenty years of selenium fertilization. Agrifood Research Reports 69, pp 8–13

  • Bagci SA, Ekiz H, Yilmaz A, Cakmak I (2007) Effects of zinc deficiency and drought on grain yield of field-grown wheat cultivars in Central Anatolia. J Agron Crop Sci 193:198–206

    Article  CAS  Google Scholar 

  • Bouis HE (2003) Micronutrient fortification of plants through plant breeding: can it improve nutrition in man at low cost? Proc Nutr Soc 62:403–411

    Article  PubMed  Google Scholar 

  • Bouis HE, Graham RD, Welch RM (2000) The Consultative Group on International Agricultural Research (CGIAR) Micronutrients Project: Justifications and objectives. Food Nutr Bull 21:374–381

    Google Scholar 

  • Braun HJ (1999) Prospects of turkey’s wheat industry, Breeding and Biotechnology. In: Ekiz H (ed) Hububat sempozyum, International Winter Cereal Research Center-Konya, pp 1–744

  • Brennan RF (1992) The effect of zinc fertilizer on take-all and the grain yield of wheat grown on zinc-deficient soils of the Esperance region, Western Australia. Fert Res 31:215–219

    Article  CAS  Google Scholar 

  • Broadley MR, White PJ, Bryson RJ, Meacham MC, Bowen HC, Johnson SE, Hawkesford MJ, McGrath SP, Zhao FJ, Breward N, Harriman M, Tucker M (2006) Biofortification of UK food crops with selenium. Proc Nutr Soc 65:169–181

    Article  PubMed  CAS  Google Scholar 

  • Buerkert A, Haake C, Ruckwied M, Marschner H (1998) Phosphorus application affects the nutritional quality of millet grain in the Sahel. Field Crops Res 57:223–235

    Article  Google Scholar 

  • Cakmak I (2000) Role of zinc in protecting plant cells from reactive oxygen species. New Phytol 146:185–205

    Article  CAS  Google Scholar 

  • Cakmak I (2002) Plant nutrition research: Priorities to meet human needs for food in sustainable ways. Plant Soil 247:3–24

    Article  CAS  Google Scholar 

  • Cakmak I (2004) Identification and correction of widespread zinc deficiency in Turkey, A success story. IFS Proceedings No. 552, International Fertiliser Society, York. UK, pp 1–28

  • Cakmak I, Marschner H (1986) Mechanism of phosphorus induced zinc deficiency in cotton. I. Zinc deficiency-enhanced uptake rate of phosphorus. Physiol Plant 68:483–490

    Article  CAS  Google Scholar 

  • Cakmak I, Marschner H (1987) Mechanism of phosphorus induced zinc deficiency in cotton III. Changes in physiological availability of zinc in plants. Physiol Plant 70:13–20

    Article  CAS  Google Scholar 

  • Cakmak I, Marschner H (1988) Increase in membrane permeability and exudation in roots of zinc deficient plants. J Plant Physiol 132:356–361

    CAS  Google Scholar 

  • Cakmak I, Yilmaz A, Ekiz H, Torun B, Erenoglu B, Braun HJ (1996) Zinc deficiency as a critical nutritional problem in wheat production in Central Anatolia. Plant Soil 180:165–172

    Article  CAS  Google Scholar 

  • Cakmak I, Ekiz H, Yilmaz A, Torun B, Koleli N, Gultekin I, Alkan A, Eker S (1997) Differential response of rye, triticale, bread wheat and durum wheats to zinc deficiency in calcareous soils. Plant Soil 188:1–10

    Article  CAS  Google Scholar 

  • Cakmak I, Kalayci M, Ekiz H, Braun HJ, Yilmaz A (1999) Zinc deficiency as an actual problem in plant and human nutrition in Turkey: A NATO-Science for Stability Project. Field Crops Res 60:175–188

    Article  Google Scholar 

  • Cakmak I, Torun A, Millet E, Feldman M, Fahima T, Korol A, Nevo E, Braun HJ, Ozkan H (2004) Triticum dicoccoides: an important genetic resource for increasing zinc and iron concentration in modern cultivated wheat. Soil Sci Plant Nutr 50:1047–1054

    CAS  Google Scholar 

  • Calderini DF, Ortiz-Monasterio I (2003) Are synthetic hexaploids a means of increasing grain element concentrations in wheat? Euphytica 134:169–178

    Article  CAS  Google Scholar 

  • Calderini D, Reynolds MP, Slafer GA (2006) Source-sink effects on grain weight of bread wheat, durum wheat, and triticale at different locations. Aust J Agric Res 57:227–233

    Article  Google Scholar 

  • Catlett KM, Heil DM, Lindsay WL, Ebinger MH (2002) Soil chemical properties controlling zinc (2+) activity in 18 Colorado soils. Soil Sci Soc Am J 66:1182–1189

    Article  CAS  Google Scholar 

  • Combs GF Jr, Gray WP (1998) Chemopreventive agents: selenium. Pharmacol Ther 79:179–192

    Article  PubMed  CAS  Google Scholar 

  • Distelfeld A, Cakmak I, Peleg Z, Ozturk L, Yazici AM, Budak H, Saranga Y, Fahima T (2007) Multiple QTL-effects of wheat Gpc-B1 locus on grain protein and micronutrient concentrations. Physiol Plant 129:635–643

    Article  CAS  Google Scholar 

  • Drakakaki G, Marcel S, Glahn RP, Lund L, Periagh S, Fischer R, Christou P, Stoger E (2005) Endosperm specific co-expression of recombinant soybean ferritin and Aspergillus phytase in maize results in significant increases in the levels of bioavailable iron. Plant Mol Biol 59:869–880

    Article  PubMed  CAS  Google Scholar 

  • Egli I, Davidsson L, Zeder C, Walczyk T, Hurrell R (2004) Dephytinization of a complementary food based on wheat and soy increases zinc, but not copper, apparent absorption in adults. J Nutr 134:1077–1080

    PubMed  CAS  Google Scholar 

  • Eide DJ (2006) Zinc transporters and the cellular trafficking of zinc. Biochim Biophys Acta 1763:711–722

    Article  PubMed  CAS  Google Scholar 

  • Ekholm P, Eurola M, Venalainen E-R (2005) Selenium content of foods and diets in Finland. In: Eurola M (ed) Proceedings twenty years of selenium fertilization. Agrifood Research Reports 69, pp 39–45

  • Ekiz H, Bagci, SA, Kiral AS, Eker S, Gultekin I, Alkan A, Cakmak I (1998) Effects of zinc fertilization and irrigation on grain yield and zinc concentration of various cereals grown in zinc-deficient calcareous soil. J Plant Nutr 21:2245–2256

    CAS  Google Scholar 

  • Ellis BG, Davis JF, Judy WH (1965) Effect of method of incorporation of zinc in fertilizer on zinc uptake and yield of pea beans (Phaseolus vulgaris). Soil Sci Soc Am Proc 29:635–636

    Article  Google Scholar 

  • Erdal I, Yilmaz A, Taban S, Eker S, Cakmak I (2002) Phytic acid and phosphorus concentrations in seeds of wheat cultivars grown with and without zinc fertilization. J Plant Nutr 25:113–127

    Article  CAS  Google Scholar 

  • Erenoglu B (1995) Zinc adsorption and desorption characteristics in selected soils from Central Anatolia, GAP and Cukurova Regions (in Turkish). MSc Thesis, Cukurova University, Adana

  • Eyupoglu F, Kurucu N, Sanisa U (1994) Status of plant available micronutrients in Turkish soils (in Turkish). Annual Report, Report No: R-118. Soil and Fertilizer Research Institute, Ankara, 1994; 25–32

  • Fahima T, Distelfeld A, Peleg Z, Ozturk L, Yazici AM, Saranga Y, Cakmak I (2006) Multiple QTL-effects on grain zinc, iron and protein concentrations localized within a 250-kb interval on chromosome 6BS of wheat. In: 8th International Congress of Plant Molecular Biology, 20–25 August 2006, Adelaide, Australia, p 30

  • Feil B, Fossati D (1995) Mineral composition of triticale grains as related to grain yield and grain protein. Crop Sci 35:1426–1431

    Article  Google Scholar 

  • Ghandilyan A, Vreugdenhil D, Aarts MGM (2006) Progress in the genetic understanding of plant iron and zinc. Physiol Plant 126:407–417

    Article  CAS  Google Scholar 

  • Gibson RS (2006) Zinc: the missing link in combating micronutrient malnutrition in developing countries. Proc Nutr Soc 65:51–60

    Article  PubMed  CAS  Google Scholar 

  • Gibson RS (2007) The role of diet- and host-related factors in nutrient bioavailability and thus in nutrient-based dietary requirement estimates. Food Nutr Bull 28:77–100

    Google Scholar 

  • Goto F, Yoshihara T, Shigemoto N, Toki S, Takaiwa F (1999) Iron fortification of rice seed by the soybean ferritin gene. Nat Biotech 17:282–286

    Article  CAS  Google Scholar 

  • Graham RD, Welch RM (1996) Breeding for staple-food crops with high micronutrient density: Working Papers on Agricultural Strategies for Micronutrients, No.3. International Food Policy Institute, Washington DC

  • Graham RD, Ascher JS, Hynes SC (1992) Selection of zinc-efficient cereal genotypes for soils of low zinc status. Plant Soil 146:241–250

    Article  CAS  Google Scholar 

  • Graham R, Senadhira D, Bebe S, Iglesias C, Monasterio I (1999) Breeding for micronutrient density in edible portions of staple food crops: conventional approaches. Field Crops Res 60:57–80

    Article  Google Scholar 

  • Guttieri MJ, Peterson KM, Souza EJ (2006) Agronomic performance of low phytic acid wheat. Crop Sci 46:2623–2629

    Article  CAS  Google Scholar 

  • Harris D, Rashid D, Miraj G, Arif M, Shah H (2007) ‘On-farm’ seed priming with zinc sulphate solution – A cost-effective way to increase the maize yields of resource-poor farmers. Field Crops Res 102:119–127

    Article  Google Scholar 

  • Harrison PM, Arosio P (1996) Molecular properties, iron storage function and cellular regulation. Biochem Biophys Acta 1275:161–203

    Article  PubMed  Google Scholar 

  • Hartemink AE (2006) Assessing soil fertility decline in the tropics using soil chemical data. Adv Agron 89:179–225

    Google Scholar 

  • Hotz C, Brown KH (2004) Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull 25:94–204

    Google Scholar 

  • Hotz C, Gibson RS (2007) Traditional food-processing and preparation practices to enhance the bioavailability of micronutrients in plant-based diets. J Nutr 137:1097–1100

    PubMed  CAS  Google Scholar 

  • Huang C, Barker SJ, Langridge P, Smith FW, Graham RD (2000) Zinc deficiency up-regulates expression of high-affinity phosphate transporter genes in both phosphate-sufficient and -deficient barley roots. Plant Physiol 124:415–422

    Article  PubMed  CAS  Google Scholar 

  • Kalayci M, Torun B, Eker S, Aydin M, Ozturk L, Cakmak I (1999) Grain yield, zinc efficiency and zinc concentration of wheat cultivars grown in a zinc-deficient calcareous soil in field and greenhouse. Field Crops Res 63:87–98

    Article  Google Scholar 

  • Lindsay WL (1991) Inorganic equilibria affecting micronutrients in soils. In: Mortvedt JJ, Cox FR, Shuman LM, Welch RM (eds) Micronutrients in Agriculture. SSSA Book Series No. 4. Madison, WI. pp. 89–112

  • Lindsay WL, Norvell WA (1978) Development of a DTPA soil test for zinc, iron, manganese and copper. Soil Sci Soc Amer J 42:421–428

    Article  CAS  Google Scholar 

  • Loneragan JF, Grunes DL, Welch RM, Aduayi EA, Tengah A, Lazar VA, Cary EE (1982) Phosphorus accumulation and toxicity in leaves in relation to zinc supply. Soil Sci Soc Amer J 46:345–352

    Article  CAS  Google Scholar 

  • Lott JNA, Spitzer E (1980) X-ray analysis studies of elements stored in protein body globoid crystals of Triticum grains. Plant Physiol 66:494–499

    PubMed  CAS  Google Scholar 

  • Lucca P, Hurrell R, Potrykus I (2001) Genetic engineering approaches to improve the bioavailability and the level of iron in rice grains. Theor Appl Genet 102:392–397

    Article  CAS  Google Scholar 

  • Lucca P, Poletti S, Sautter C (2006) Genetic engineering approaches to enrich rice with iron and vitamin A. Physiol Plant 126:291–303

    Article  CAS  Google Scholar 

  • Marschner H (1993) Zinc uptake from soils. In: Robson AD (ed) Zinc in Soils and Plants. Kluwer, Dordrecht, The Netherlands, pp 59–77

    Google Scholar 

  • Marschner H (1995) Mineral nutrition of higher plants. 2nd edn. Academic, London

    Google Scholar 

  • Martens DC, Westermann DT (1991) Fertilizer applications for correcting micronutrient deficiencies. In: Mortvedt JJ, Cox FR, Shuman LM, Welch RM (eds) Micronutrients in Agriculture. SSSA Book Series No. 4. Madison, WI. pp. 549–592

  • Mazzolini AP, Pallaghy CK, Legge GJF (1985) Quantitative microanalysis of Mn, Zn, and other elements in mature wheat seed. New Phytol 100:483–509

    Article  CAS  Google Scholar 

  • Mortvedt JJ (1991) Micronutrient fertilizer technology. In: Mortvedt JJ, Cox FR, Shuman LM, Welch RM (eds) Micronutrients in Agriculture. SSSA Book Series No. 4. Madison, WI. pp. 89–112

  • Mortvedt JJ, Gilkes RJ (1993) Zinc fertilizers. In: Robson AD (ed) Zinc in soils and plants. Kluwer, Dordrecht, The Netherlands, pp 33–44

    Google Scholar 

  • Morgonuov A, Gómez-Becerra HF, Abugalieva A, Dzhunusova M, Yessimbekova M, Muminjanov H, Zelenskiy Y, Ozturk L, Cakmak I (2007) Iron and zinc grain density in common wheat grown in Central Asia. Euphytica 155:193–203

    Article  Google Scholar 

  • Morris ER, Ellis R (1989) Usefulness of the dietary phytic acid/zinc molar ratio as an index of zinc bioavailability to rats and humans. Biol Trace Elem Res 19:107–117

    PubMed  CAS  Google Scholar 

  • National Research Council Recommended Dietary Allowances (1989) Subcommittee on the Tenth Edition of the RDAs Food and Nutrition Board, Commission on Life Sciences 10th ed. National Academy Press, Washington, DC

  • Obrador A, Novillo J, Alvarez JM (2003) Mobility and availability to plants of two zinc sources applied to a calcareous soil. Soil Sci Soc Am J 67:564–572

    Article  CAS  Google Scholar 

  • Oltmans SE, Fehr WR, Welke GA, Raboy V, Peterson KL (2005) Agronomic and seeds traits of soybean lines with low-phytate phosphorus. Crop Sci 45:593–598

    Article  CAS  Google Scholar 

  • Ozturk L, Yazici MA, Yucel C, Torun A, Cekic C, Bagci A, Ozkan H, Braun H-J, Sayers Z, Cakmak I (2006) Concentration and localization of zinc during seed development and germination in wheat. Physiol Plant 128:144–152

    Article  CAS  Google Scholar 

  • Parker DR (1997) Responses of six crop species to solution Zn2+activities buffered with HEDTA. Soil Sci Soc Am J 61:167–176

    Article  CAS  Google Scholar 

  • Peleg Z, Saranga Y, Yazici A, Fahima T, Ozturk L, Cakmak I (2008) Grain zinc, iron and protein concentrations and zinc-efficiency in wild emmer wheat under contrasting irrigation regimes. Plant Soil (in press)

  • Peterson CJ, Johnson VA, Mattern PJ (1986) Influence of cultivar and environment on mineral and protein concentrations of wheat flour, bran, and grain. Cereal Chem 63:183–186

    CAS  Google Scholar 

  • Pfeiffer WH, McClafferty B (2007) Biofortification: Breeding Micronutrient-Dense Crops. In: Kang MS (Ed) Breeding major food staples. Blackwell Science Ltd (in press)

  • Prasad AS (2007) Zinc: Mechanisms of host defense. J Nutr 137:1345–1349

    PubMed  CAS  Google Scholar 

  • Qu LQ, Yoshihara T, Ooyama A, Goto F, Takaiwa F (2005) Iron accumulation does not parallel the high expression level of ferritin in transgenic rice seeds. Planta 222:225–233

    Article  CAS  Google Scholar 

  • Ramesh SA, Choimes S, Schachtman D (2004) Over-expression of an Arabidopsis zinc transporter in Hordeum vulgare increases short term zinc uptake after zinc deprivation and seed zinc content. Plant Mol Biol 54:373–385

    Article  PubMed  CAS  Google Scholar 

  • Rattan RK, Deb DL (1981) Self-diffusion of zinc and iron in soils as affected by pH, CaCO3, moisture, carrier and phosphorus levels. Plant Soil 63:377—393

    Article  CAS  Google Scholar 

  • Rayman MP (2005) Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc 64:527–542

    Article  PubMed  CAS  Google Scholar 

  • Rengel Z (1997) Root exudation and microflora populations in rhizosphere of crop genotypes differing in tolerance to micronutrient deficiency. Plant and Soil 196:255–260

    Article  CAS  Google Scholar 

  • Rengel Z, Graham RD (1995) Importance of seed zinc content for wheat growth on zinc-deficient soil. I. Vegetative growth. Plant Soil 173:259–266

    Article  CAS  Google Scholar 

  • Rengel Z, Batten GD, Crowley DE (1999) Agronomic approaches for improving the micronutrient density in edible portions of field crops. Field Crops Res 60:27–40

    Article  Google Scholar 

  • Sarkar AN, Wyn Jones RG (1982) Effect of rhizosphere pH on the availability and uptake of Fe, Mn and Zn. Plant Soil 66:361–372

    Article  CAS  Google Scholar 

  • Schachtman DP, Barker SJ (1999) Molecular approaches for increasing the micronutrient density in edible portions of food crops. Field Crop Res 60:81–92

    Article  Google Scholar 

  • Siddiqui IA, Shaukat SS, Hamid M (2002) Role of zinc in rhizobacteria-mediated suppression of root-infecting fungi and root-knot nematode. J Phytopathol 150:569–575

    Article  CAS  Google Scholar 

  • Sillanpaa M (1982) Micro nutrients and the nutrient status of soils. A global study. FAO Soils Bulletin, No.48, FAO, Rome

  • Slaton NA, Wilson CE, Ntamatungiro S, Norman RJ, Boothe DL (2001) Evaluation of zinc seed treatments for rice. Agron J 93:152–157

    Article  CAS  Google Scholar 

  • Somasundar P, Riggs D, Jackson B, Cunningham C, Vona-Davis L, McFadden DW (2005) Inositol hexaphophate (IP6): a novel treatment for pancreatic cancer. J Surg Res 126:199–203

    Article  PubMed  CAS  Google Scholar 

  • Stein AJ, Nestel P, Meenakshi JV, Qaim M, Sachdev HPS, Bhutta ZA (2007) Plant breeding to control zinc deficiency in India: how cost-effective is biofortification? Pub Health Nutr 10:492–501

    Article  Google Scholar 

  • Streeter TC, Rengel Z, Neate SM, Graham RD (2001) Zinc fertilisation increases tolerance to Rhizoctonia solani (AG 8) in Medicago truncatula. Plant Soil 228:233–242

    Article  CAS  Google Scholar 

  • Takkar PN, Walker CD (1993) The distribution and correction of zinc deficiency. In: Robson AD (ed) Zinc in soils and plants. Kluwer, Dordrecht, The Netherlands, pp 151–166

    Google Scholar 

  • Tan ZX, Lal R, Wiebe KD (2005) Global soil nutrient depletion and yield reduction. J Sust Agric 26:123–146

    Article  Google Scholar 

  • Tandon HLS (1995) Major nutritional constraints to crop production and the soil fertility management strategies in different agroclimatic regions of Asia. In: Proceedings of the International Potash Institute Colloquium on Potassium in Asia: Balanced Fertilization to Increase and Sustain Agricultural Production. Chiang Mai, Thailand, 21–24 February, 1995. International Potash Institute, Basel, pp 43–72

  • Uauy C, Distelfeld A, Fahima T, Blechl A, Dubcovsky J (2006) A NAC gene regulating senescence improves grain protein, zinc, and iron content in wheat. Science 314:1298–1301

    Article  PubMed  CAS  Google Scholar 

  • Vasconcelos M, Datta K, Oliva N, Khalekuzzaman M, Torrizo L, Krishnan S, Oliveria M, Goto F, Data SK (2003) Enhanced iron and zinc accumulation in transgenic rice with the ferritin gene. Plant Sci 164:371–378

    Article  CAS  Google Scholar 

  • Vucenik I, Shamsuddin AM (2003) Cancer inhibition by inositol hexaphosphate (IP6) and inositol: from laboratory to clinic. J Nutr 133:3778–3784

    Google Scholar 

  • Welch RM (1999) Importance of seed mineral nutrient reserves in crop growth and development. In: Rengel Z (ed) Mineral nutrition of crops: Fundamental mechanisms and implications. Food Products Press, New York pp 205–226

    Google Scholar 

  • Welch RM, Graham RD (2004) Breeding for micronutrients in staple food crops from a human nutrition perspective. J Exp Bot 55:353–364

    Article  PubMed  CAS  Google Scholar 

  • Welch RM, Webb MJ, Loneragan JF (1982) Zinc in membrane function and its role in phosphorus toxicity. In: Scaife A (ed) Proceedings of the Ninth Plant Nutrition Colloquium. Warwick, UK. Wallingford, UK: CAB International, pp 710–715

  • White PJ, Broadley MR (2005) Biofortifying crops with essential mineral elements. Trends Plant Sci 10:586–593

    Article  PubMed  CAS  Google Scholar 

  • White JG, Zasoski RJ (1999) Mapping soil micronutrients. Field Crop Res 60:11–26

    Article  Google Scholar 

  • Wilkinson HF, Loneragan JF, Quick JP (1968) The movement of zinc to plant roots. Soil Sci Soc Amer Proc 32:831–833

    Article  Google Scholar 

  • World Health Organization (WHO) The World Health Report 2002 Geneva: WHO, 2002

  • Yilmaz A, Ekiz H, Torun B, Gultekin I, Karanlik S, Bagci SA, Cakmak I (1997) Effect of different zinc application methods on grain yield and zinc concentration in wheat grown on zinc-deficient calcareous soils in Central Anatolia. J Plant Nutr 20:461–471

    Article  CAS  Google Scholar 

  • Yilmaz A, Ekiz H, Gültekin I, Torun B, Barut H, Karanlik S, Cakmak I (1998) Effect of seed zinc content on grain yield and zinc concentration of wheat grown in zinc-deficient calcareous soils. J Plant Nutr 21:2257–2264

    CAS  Google Scholar 

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Acknowledgements

The author is grateful to Prof. Dr. R. M. Welch (Cornell University), Prof. Dr. Zed Rengel (Western Australia University), Dr. W. Pfeiffer (CIAT-HarvestPlus), Dr. I. Monasterio (CIMMYT) and Dr. L Ozturk (Sabanci University) for very valuable comments on the manuscript, and to HarvestPlus biofortification challenge program (http://www.harvestplus.org) and the State Planning Organization of the Turkish Republic for the financial support.

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Cakmak, I. Enrichment of cereal grains with zinc: Agronomic or genetic biofortification?. Plant Soil 302, 1–17 (2008). https://doi.org/10.1007/s11104-007-9466-3

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