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Cytotoxic activity and mechanism of action of metabolites from the Goniothalamus genus

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Abstract

The World Health Organization estimates that 4 billion people or 80 % of the population use plants for curative purposes or for their natural health benefits. Accordingly, biodiversity is an important source of active natural products especially used in traditional medicine as healers transmitted knowledge of traditional usage of medicinal plants from generation to generation whereas pharmacologically active compounds within remained obscure. The present review documents cytotoxicity and anti-cancer potential of known compounds of the Goniothalamus species from the Annonaceae family existing in tropical and subtropical Asia and being intensively used for medicinal purposes.

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Acknowledgments

M.D.’s research is financially supported by “Recherche Cancer et Sang” foundation, by «Recherches Scientifiques Luxembourg» asbl, by «Een Häerz fir Kriibskrank Kanner» association, the Action Lions “Vaincre le Cancer” Luxembourg, Télévie Luxembourg, the National Research Foundation (NRF) by the MEST of Korea for Tumor Microenvironment Global Core Research Center (GCRC) grant, [Grant Number 2012-0001184]. Choo is grateful to the UiTM’s RIF and PSI fund for the financial support.

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Authors and Affiliations

  1. MedChem Herbal Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, 42300, Puncak Alam, Selangor, Malaysia

    Chee-Yan Choo & Norkamilah Abdullah

  2. Drug Discovery and Health Core, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia

    Chee-Yan Choo

  3. Department of Pharmacy, College of Pharmacy, Seoul National University, Building 20 Room 303, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, South Korea

    Marc Diederich

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  1. Chee-Yan Choo
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  2. Norkamilah Abdullah
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Correspondence to Chee-Yan Choo or Marc Diederich.

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Choo, CY., Abdullah, N. & Diederich, M. Cytotoxic activity and mechanism of action of metabolites from the Goniothalamus genus. Phytochem Rev 13, 835–851 (2014). https://doi.org/10.1007/s11101-014-9372-2

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  • DOI: https://doi.org/10.1007/s11101-014-9372-2

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