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Anticancer effects of bioactive berry compounds

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Abstract

In the present review, we describe chemical and chemopreventive properties as well as health benefits of both extracts and bioactive compounds from various types of berries including small soft-fleshed edible berries and from berry-like fruits such as strawberries, raspberries, blackberries, blueberries, mulberries, currants, gooseberries, elderberries, açai berries, and pomegranates. In particular, we describe how berry-derided phytochemicals, including anthocyanidins, proanthocyanidins, flavonols, flavanols, stilbenoids, terpenoids, ellagitannins, and ellagic acid target oxidative and UV radiation stress-induced DNA damage, Helicobacter pilori infection, pro-inflammatory as well as the major cancer hallmarks.

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Abbreviations

AP-1:

Activation protein 1

BAD:

Bcl-2 associated death promoter

Bcl-2:

B cell lymphoma-2

cdk:

Cyclin dependent kinase

COX:

Cyclooxygenase

ERK:

Extracellular signal-related kinase

IL:

Interleukin

iNOS:

Inducible nitric oxide synthase

JAK:

Janus kinase

JNK:

c-Jun N-terminal kinase

LPS:

Lipopolysaccharide

MAP2K:

MAPK kinase

MAP3K:

MAP2K kinase

MAPK:

Mitogen-activated protein kinase

MMP:

Matrix metalloproteinase

NF-κB:

Nuclear factor-κB

NO:

Nitric oxide

ORAC:

Oxygen radical absorbance capacities

PGE2 :

Prostaglandin E2

PI-3 K:

Phosphoinositide 3-kinase

PKC:

Protein kinase C

PIP2 :

Phosphatidylinostol (3,4)-bisphosphate

PIP3 :

Phosphatidylinostol (3,4,5)-triphosphate

Rb:

Retinoblastoma protein

ROS:

Reactive oxygen species

SAR:

Structure–activity relationship

STAT:

Signal transducer and activator of transcription

TIMP:

Tissue inhibitor of matrix proteinase

TNF-α:

Transcription factor-α

USDA:

United States Department of Agriculture

UV:

Ultraviolet

VEGF:

Vascular endothelial growth factor

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Acknowledgments

Research at the Laboratoire de Biologie Moléculaire et Cellulaire du Cancer (LBMCC) is financially supported by “Recherche Cancer et Sang” foundation, by «Recherches Scientifiques Luxembourg» asbl, by «Een Häerz fir Kriibskrank Kanner» association, the Action Lions “Vaincre le Cancer” Luxembourg, The Fonds National de la Recherche Luxembourg, Televie Luxembourg and the Foundation for Scientific Cooperation between Germany and Luxemburg is thanked for additional support. Further support was received from the European Union (ITN “RedCat” 215009 and Interreg IVa project “Corena”). MD is supported by the National Research Foundation (NRF) by the MEST of Korea for Tumor Microenvironment Global Core Research Center (GCRC) grant, [Grant Number 2012-0001184]; by the Seoul National University Research grant and by the Research Settlement Fund for the new faculty of SNU.

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  1. Laboratoire de Biologie Moléculaire et Cellulaire du Cancer, Fondation de Recherche Cancer et Sang, Hôpital Kirchberg, 9 Rue Edward Steichen, 2540, Luxembourg, Luxembourg

    Florence Folmer & Mario Dicato

  2. Division of Applied Medicine, Institute of Medical Science, School of Medicine and Dentistry, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK

    Florence Folmer, Umesh Basavaraju, Georgina Hold & Emad El-Omar

  3. Marine Biodiscovery Centre, Chemistry Department, School of Natural and Computing Sciences, University of Aberdeen, Aberdeen, AB24 3UE, Scotland, UK

    Florence Folmer & Marcel Jaspars

  4. Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea

    Marc Diederich

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Correspondence to Marc Diederich.

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Folmer, F., Basavaraju, U., Jaspars, M. et al. Anticancer effects of bioactive berry compounds. Phytochem Rev 13, 295–322 (2014). https://doi.org/10.1007/s11101-013-9319-z

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