Article

Phytochemistry Reviews

, Volume 11, Issue 4, pp 567-616

The therapeutic lead potential of metabolites obtained from natural sources for the treatment of peptic ulcer

  • Luiz Carlos Klein-JúniorAffiliated withPrograma de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí, UNIVALI Email author 
  • , José Roberto SantinAffiliated withPrograma de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí, UNIVALI
  • , Rivaldo NieroAffiliated withPrograma de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí, UNIVALI
  • , Sérgio Faloni de AndradeAffiliated withPrograma de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí, UNIVALI
  • , Valdir Cechinel-FilhoAffiliated withPrograma de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas, Universidade do Vale do Itajaí, UNIVALI

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Abstract

For over a century, ulcer has been a major cause of morbidity and mortality. Its treatment has progressed from vagotomy to proton pump inhibitors. However, the drugs used produce many adverse effects and are less effective than they ought to be. Therefore, there is a growing interest in alternative therapies and the use of natural products. This review emphasizes recent studies involving naturally occurring antiulcer metabolites, categorized according to their chemical structure. Both terrestrial and marine sources are included. More than a hundred and fifty different compounds are presented, and where possible, their main mechanisms of action are summarized. Considering that Helicobacter pylori is an important causal factor in the pathogenesis of ulcer disease, an overview of some natural compounds with anti-H. pylori activity is presented.

Keywords

Ulcer Secondary metabolites Gastroprotection