Knowledge and attitudes of American pharmacists concerning sulfonamide allergy cross-reactivity
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Objective Pharmacists are commonly confronted with patients with a history of sulfonamide allergy. Basic immunologic and clinical data suggest a low likelihood of a patient with a history of sulfonamide hypersensitivity developing an allergic reaction to a non-antimicrobial sulfonamide drug. We conducted a survey to describe the knowledge and attitudes of licensed pharmacists concerning sulfonamide allergy cross-reactivity. Methods A survey instrument was developed and sent to all licensed pharmacists in the state of Iowa. The survey recorded demographic information and included six patient scenarios designed to elicit responses concerning sulfonamide allergy cross-reactivity with a number of non-antimicrobial sulfonamides. Results A total of 421 surveys were returned for a 39% response rate. There was a wide discrepancy in approaches to patients with a history of sulfonamide allergy prescribed a sulfonamide containing non-antibiotic. Differences depended on previous history of tolerating the medication in question, the degree of cautionary statements in product literature, and the familiarity the pharmacist had with the product. Conclusion Our survey suggests a significant diversity in knowledge and attitudes of pharmacists concerning cross-reactivity of sulfonamide antimicrobials and other drugs with a sulfonamide moiety. Depth of training in this area may be an associative factor.
- Joint Commission. Sentinel Event Policy and Procedures. July 2007. http://www.jointcommission.org/NR/rdonlyres/F84F9DC6-A5DA-490F-A91F-A9FCE26347C4/0/SE_chapter_july07.pdf. Accessed 5 Dec 2009.
- Demoly P, Gomes ER. Drug hypersensitivities: definition, epidemiology and risk factors. Eur Ann Allergy Clin Immunol. 2005;37:202–6.
- Farrell J, Naisbitt DJ, Drummond NS, et al. Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and humans. J Pharmacol Exp Ther. 2003;306:229–37. CrossRef
- Schnipper JL, Kirwin JL, Cotugno MC, et al. Role of pharmacist counseling in preventing adverse drug events after hospitalization. Arch Intern Med. 2006;166:565–71. CrossRef
- Patterson R, Bellow AE, Lefkowith J. Immunologic tolerability profile of celecoxib. Clin Ther. 1999;21:2065–79. CrossRef
- Strom BL, Schinnar R, Apter AJ, et al. Absence of cross-reactivity between sulfonamide antimicrobials and sulfonamide nonantimicrobials. N Engl J Med. 2003;349:1628–35. CrossRef
- Knowledge and attitudes of American pharmacists concerning sulfonamide allergy cross-reactivity
Pharmacy World & Science
Volume 32, Issue 3 , pp 343-346
- Cover Date
- Print ISSN
- Online ISSN
- Springer Netherlands
- Additional Links
- Pharmacist behavior
- United States
- Industry Sectors