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A new Strategy to Improve Drug Delivery to the Maxillary Sinuses: The Frequency Sweep Acoustic Airflow

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Abstract

Purpose

Enhancement of intranasal sinus deposition involves nebulization of a drug superimposed by an acoustic airflow. We investigated the impact of fixed frequency versus frequency sweep acoustic airflow on the improvement of aerosolized drug penetration into maxillary sinuses.

Methods

Fixed frequency and frequency sweep acoustic airflow were generated using a nebulizing system of variable frequency. The effect of sweep cycle and intensity variation was studied on the intranasal sinus deposition. We used a nasal replica created from CT scans using 3D printing. Sodium fluoride and gentamicin were chosen as markers.

Results

Studies performed using fixed frequency acoustic airflow showed that each of maxillary sinuses of the nasal replica required specific frequency for the optimal aerosol deposition. Intranasal sinus drug deposition experiments under the effect of the frequency sweep acoustic airflow showed an optimal aerosol deposition into both maxillary sinus of the nasal replica. Studies on the effect of the duration of the sweep cycle showed that the shorter the cycle the better the deposition.

Conclusions

We demonstrate the benefit of frequency sweep acoustic airflow on drug deposition into maxillary sinuses. However further in vivo studies have to be conducted since delivery rates cannot be obviously determined from a nasal replica.

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Abbreviations

CRS:

Chronic rhinosinusitis

FESS:

Functional endoscopic sinus surgery

LC-MS/MS:

Liquid chromatography-tandem mass spectrometry

LMS:

Left maxillary sinus

MS:

Maxillary sinuses

NaF:

Sodium fluoride

RMS:

Right maxillary sinus

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Author’s Contributions

JP, AEM, LN, LL contributed to the conception and the design of research.

AEM, JP, LN, and XD materially participated in the acquisition of data and research experiments analysis.

AEM, LL and JP were involved in interpretation of data and with drafting article.

LN, XD, and all others were involved with reviewing the article.

All authors have approved the final version of this article.

Author information

Authors and Affiliations

  1. Ecole Nationale Supérieure des Mines, CIS-EMSE, Sainbiose UMR INSERM 1059, SFR FED 4166 - IFRESIS, F-42023, Saint-Etienne, France

    Amira El Merhie, Laurent Navarro, Lara Leclerc & Jérémie Pourchez

  2. Laboratoire de Pharmacologie – Toxicologie, Sainbiose UMR INSERM 1059, CHU de Saint-Etienne, F-42055, Saint-Etienne, France

    Xavier Delavenne

Authors
  1. Amira El Merhie
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  2. Laurent Navarro
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  3. Xavier Delavenne
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  4. Lara Leclerc
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  5. Jérémie Pourchez
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Corresponding author

Correspondence to Lara Leclerc.

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Declaration of Interest and Funding

There is no conflict of interest to declare. This work was not supported by industrial funding or European or French research grant (University “Ecole des Mines” – funded research).

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El Merhie, A., Navarro, L., Delavenne, X. et al. A new Strategy to Improve Drug Delivery to the Maxillary Sinuses: The Frequency Sweep Acoustic Airflow. Pharm Res 33, 1074–1084 (2016). https://doi.org/10.1007/s11095-015-1851-7

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  • DOI: https://doi.org/10.1007/s11095-015-1851-7

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