Expert Review

Pharmaceutical Research

, Volume 26, Issue 5, pp 1025-1058

Methods for the Preparation and Manufacture of Polymeric Nanoparticles

  • Christine VauthierAffiliated withCNRS UMR 8612, Université Paris Sud-11 Email author 
  • , Kawthar BouchemalAffiliated withCNRS UMR 8612, Université Paris Sud-11

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Abstract

This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules. The first part summarizes the basic principle of each method of nanoparticle preparation. It presents the most recent innovations and progresses obtained over the last decade and which were not included in previous reviews on the subject. Strategies for the obtaining of nanoparticles with controlled in vivo fate are described in the second part of the review. A paragraph summarizing scaling up of nanoparticle production and presenting corresponding pilot set-up is considered in the third part of the review. Treatments of nanoparticles, applied after the synthesis, are described in the next part including purification, sterilization, lyophilization and concentration. Finally, methods to obtain labelled nanoparticles for in vitro and in vivo investigations are described in the last part of this review.

KEY WORDS

gel nanocapsules nanospheres polyelectrolyte complex polymerization precipitation purification scale-up