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Rapid HPLC-MS/MS Determination of Carbamazepine and Carbamazepine-10,11-Epoxide

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A rapid HPLC-MS/MS method for simultaneous determination of carbamazepine and carbamazepine- 10,11-epoxide in human blood serum was developed. The analytical range for carbamazepine was 50 – 20,000 ng/mL; for carbamazepine-10,11-epoxide, 5 – 2,000 ng/mL. This allowed the developed method to be used for therapeutic drug monitoring, bioequivalence studies, and an assessment of the interchangeability of carbamazepine preparations.

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Authors and Affiliations

  1. Federal Scientific Centre for Expert Evaluation of Medical Products, Ministry of Public Health of the Russian Federation, Moscow, 127051, Russia

    T. A. Rodina, A. V. Sokolov, A. B. Prokof’ev & V. V. Arkhipov

  2. I. M. Sechenov First Moscow State Medical University, Moscow, 119991, Russia

    E. S. Mel’nikov, A. V. Sokolov, A. B. Prokof’ev, V. V. Arkhipov & A. A. Aksenov

  3. I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health, Moscow, 109240, Russia

    T. A. Rodina, E. S. Mel’nikov, A. B. Prokof’ev, V. V. Arkhipov & D. L. Pozdnyakov

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  1. T. A. Rodina
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  2. E. S. Mel’nikov
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  3. A. V. Sokolov
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  4. A. B. Prokof’ev
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  5. V. V. Arkhipov
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  6. A. A. Aksenov
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  7. D. L. Pozdnyakov
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 50, No. 6, pp. 52 – 56, June, 2016.

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Rodina, T.A., Mel’nikov, E.S., Sokolov, A.V. et al. Rapid HPLC-MS/MS Determination of Carbamazepine and Carbamazepine-10,11-Epoxide. Pharm Chem J 50, 419–423 (2016). https://doi.org/10.1007/s11094-016-1462-6

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  • DOI: https://doi.org/10.1007/s11094-016-1462-6

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