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New (−)−Cytisine Derivatives with Nootropic Activity

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Pharmaceutical Chemistry Journal Aims and scope

The mnestic and antihypoxic effects of new derivatives of the quinolizidine alkaloid (−)-cytisine on acquisition of a conditioned passive avoidance reflex (CPAR) were studied in rats; effects on normobaric (jar) hypoxia were studied in mice. Screening studies showed that the benzamide and the N-(12-methylcytidin-3-yl)-N′-phenylurea not only improved learning and memory, but also increased the resistance of the brain to hypoxia.

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References

  1. V. V. Udut, A. I. Vengerovskii, N. I. Suslov, et al., Khim.-Farm. Zh., 46(8), 27 – 29 (2012); Pharm. Chem. J., 46(8), 492 – 494 (2012).

  2. B. Winblad, CNS Drug Rev., 11, 169 (2005).

    Article  CAS  PubMed  Google Scholar 

  3. R. G. Glushkov, S. D. Yuzhakov, M. V. Alekseev, et al., Khim.-Farm. Zh., 45(3), 3 – 8 (2011); Pharm. Chem. J., 45(3), 131 – 136 (2011).

  4. P. M. Joyner and R. H. Cichewicz, Nat. Prod. Rep., 28, 26 – 47 (2011).

    Article  CAS  PubMed  Google Scholar 

  5. Y. S. Mineur, O. Somenzi, and M. R. Picciotto, Neuropharmacology, 52, 1256 – 1262 (2007).

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. B. Ferger, C. Spratt, P. Teismann, et al., Eur. J. Pharmacol., 360, 155 – 163 (1998).

    Article  CAS  PubMed  Google Scholar 

  7. E. G. Perez, C. Mendez-Galvez, and B. K. Cassels, Nat. Prod. Rep., 29, 555 – 567, No. 2012.

    Article  CAS  PubMed  Google Scholar 

  8. C. C. Boido and F. Sparatore, Farmaco, 54, 438 – 451 (1999).

    Article  CAS  Google Scholar 

  9. O. Nicolotti, C. C. Boido, F. Sparatore, and A. Carotti, Farmaco, 57, 469 – 478 (2002).

    Article  CAS  PubMed  Google Scholar 

  10. A. K. Przybyl and M. Kubicki, Molec. Structure, 985, 157 – 166 (2011).

    Article  CAS  Google Scholar 

  11. I. P. Tsypysheva, A. V. Koval’skaya, N. S. Makara, et al., Khim. Prirod. Soedin., 4, 565 (2012).

    Google Scholar 

  12. I. P. Tsypysheva, A. V. Koval’skaya, A. N. Lobov, et al., Khim. Prirod. Soedin., 4, 606 (2013).

    Google Scholar 

  13. I. P. Tsypysheva, A. V. Koval’skaya, A. N. Lobov, et al., Chem. Nat. Comp., 4, 707 – 711 (2013).

    Article  Google Scholar 

  14. Yu. V. Vakhitova, I. P. Tsypysheva, M. Kh. Salimgareeva, et al., Khim. Prirod. Soedin., 3, 430 – 434 (2014).

    Google Scholar 

  15. T. W. Seale, R. Nael, S. Singh, et al., Neuroreport, 9(2), 201 – 205 (1998).

    Article  CAS  PubMed  Google Scholar 

  16. P. Tutka, T. Mroz, J. Bendarski, et al., Pharmacol. Reports, 65, 195 – 200 (2013).

    Article  CAS  Google Scholar 

  17. C. S. Cunningham and L. R. McMahon, Eur. J. Pharmacol., 654, 45 – 52 (2011).

    Article  Google Scholar 

  18. M. D. Mashkovskii, Medicines [in Russian], Meditsina, Moscow (2000), Vol. 2,

    Google Scholar 

  19. Guidelines for Conducting Preclinical Drug Studies [in Russian], A. N. Mironov, N. D. Bunatyan, et al., (eds.), Scientific Center for the Expert Evaluation of Medical Substances, Ministery of Health and Social Development of the Russian Federation, Moscow (2012), Part 1.

  20. R. U. Ostrovskaya, T. A. Gudasheva, S. S. Trofimova, and A. P. Skoldinov, The Pharmacology of Nootropes (Experimental and Clinical Studies) [in Russian], Moscow (1989), pp. 26 – 35.

  21. M. L. Belen’kii, Elements of the Quantitative Assessment of Pharmacological Effects [in Russian], Meditsinskaya Literatura, Leningrad (1963).

    Google Scholar 

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This study was supported by the Russian Foundation for Basic Research (Grant No. 12-03-00724-a) and the “Basic Sciences – Medicine” Basic Research Program of the Presidium of the Russian Academy of Sciences.

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Authors and Affiliations

  1. Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, 71 October Prospect, 450054, Ufa, Russia

    N. S. Makara, S. F. Gabdrakhmanova, T. A. Sapozhnikova, R. Yu. Khisamutdinova, A. V. Koval’skaya, I. P. Tsypysheva & F. S. Zarudii

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  1. N. S. Makara
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  2. S. F. Gabdrakhmanova
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  3. T. A. Sapozhnikova
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  4. R. Yu. Khisamutdinova
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  5. A. V. Koval’skaya
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  6. I. P. Tsypysheva
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  7. F. S. Zarudii
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Correspondence to N. S. Makara.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 49, No. 5, pp. 16 – 18, May, 2015.

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Makara, N.S., Gabdrakhmanova, S.F., Sapozhnikova, T.A. et al. New (−)−Cytisine Derivatives with Nootropic Activity. Pharm Chem J 49, 301–303 (2015). https://doi.org/10.1007/s11094-015-1283-z

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  • DOI: https://doi.org/10.1007/s11094-015-1283-z

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