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Synthesis, Antimicrobial, and Protisticidal Activity of 3-Aryloxyethyl(Benzyl)-1-Carbamoylmethyl-2-Iminobenzimidazoline Hydrochlorides

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Pharmaceutical Chemistry Journal Aims and scope

Alkylation of 2-aminobenzimidazole by methyliodide and benzyl- or 2-aryloxyethylbromides produced 1-substituted 2-aminobenzimidazoles that were quaternized by chloroacetamide to previously undescribed 3-aryloxyethyl(benzyl)-1-carbamoylmethyl-2-iminobenzimidazoline hydrochlorides. These compounds were shown to possess antibacterial activity against several pathogenic Gram-positive and Gram-negative microbes (Staphylococcus aureus, Escherichia coli) combined with pronounced protistocidal activity against the protozoa Colpoda steinii that was on the level of the clinical reference drugs.

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Acknowledgments

The work used equipment at the CCU “Molecular spectroscopy” of the IPOC, SFU, and was performed in part under the auspices of State Task, Project No. 4.196.2014/K.

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Authors and Affiliations

  1. Institute of Physical and Organic Chemistry, Southern Federal University, Rostov-on-Don, 334090, Russia

    L. N. Divaeva, A. S. Morkovnik & T. A. Kuz’menko

  2. North Caucasian Regional Scientific Research Veterinary Institute, Novocherkassk, 346421, Russia

    A. A. Zubenko, L. N. Fetisov, A. N. Bodryakov & M. A. Bodryakova

Authors
  1. L. N. Divaeva
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  2. A. S. Morkovnik
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  3. A. A. Zubenko
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  4. T. A. Kuz’menko
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  5. L. N. Fetisov
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  6. A. N. Bodryakov
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  7. M. A. Bodryakova
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Corresponding authors

Correspondence to A. S. Morkovnik or A. A. Zubenko.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 10, pp. 29 – 32, October, 2014.

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Divaeva, L.N., Morkovnik, A.S., Zubenko, A.A. et al. Synthesis, Antimicrobial, and Protisticidal Activity of 3-Aryloxyethyl(Benzyl)-1-Carbamoylmethyl-2-Iminobenzimidazoline Hydrochlorides. Pharm Chem J 48, 661–664 (2015). https://doi.org/10.1007/s11094-015-1165-4

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  • DOI: https://doi.org/10.1007/s11094-015-1165-4

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