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Development of an Immunotropic Drug Based on Coordination Compounds of a Synthetic Low Molecular Weight Thymus Peptide with Iron Ions

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
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Pharmaceutical Chemistry Journal Aims and scope

We describe here the development of the immunomodulatory agent timofer, which is a 0.0148% aqueous solution of coordination compounds of the dipeptide isoleucyl-tryptophan and iron (II) sulfate; the synthesis of the free dipeptide and the medicinal formulation timofer and its production technology are described. Interactions were studied and the composition of the coordination compounds of the isoleucyl-tryptophan dipeptide with the iron (II) ion was identified. Interaction of the peptide and a metal ion in aqueous solution was shown to result in the formation of several complex forms, due to a stepwise complex formation process.

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Authors and Affiliations

  1. Scientific Center for Drug Expertise and Control, Russian Ministry of Health, Moscow, Russia

    B. M. Kholnazarov

  2. Tadzhik National University, Dushanbe, Tadzhikistan

    N. D. Bunyatyan

  3. S. Aini Tadzhik State Pedagogical University, Dushanbe, Tadzhikistan

    A. N. Shakhmatov

  4. OOO Zand, Dushanbe, Tadzhikistan

    G. M. Bobiev

Authors
  1. B. M. Kholnazarov
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  2. N. D. Bunyatyan
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  3. A. N. Shakhmatov
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  4. G. M. Bobiev
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 9, pp. 54 – 56, September, 2014.

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Kholnazarov, B.M., Bunyatyan, N.D., Shakhmatov, A.N. et al. Development of an Immunotropic Drug Based on Coordination Compounds of a Synthetic Low Molecular Weight Thymus Peptide with Iron Ions. Pharm Chem J 48, 632–634 (2014). https://doi.org/10.1007/s11094-014-1160-1

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  • DOI: https://doi.org/10.1007/s11094-014-1160-1

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