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Method for determining the number of aldehydes in dextran polyaldehyde using 2,4-dinitrophenylhydrazine

  • Structure of Chemical Compounds, Methods of Analysis and Process Control
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Pharmaceutical Chemistry Journal Aims and scope

A method for determining the number of aldehydes in dextran polyaldehyde (DPA) was proposed. The method was based on the production of the DPAconjugate with 2,4-dinitrophenylhydrazine, reaction of which with base formed a colored product. The developed method for quantitative determination of aldehydes was distinguished from others by its simplicity and high sensitivity. Results of physicochemical studies of DPA and their derivatives were presented in order to identify their structures and formation mechanism in the presence of KMnO4.

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Authors and Affiliations

  1. Research Center of Clinical and Experimental Medicine, Siberian Division, Russian Academy of Medical Sciences, Novosibirsk, Russia

    V. S. Medvedev, A. V. Troitsky, T. N. Bystrova & V. A. Shkurupiy

Authors
  1. V. S. Medvedev
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  2. A. V. Troitsky
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  3. T. N. Bystrova
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  4. V. A. Shkurupiy
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Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 46, No. 9, pp. 52 – 56, September, 2012.

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Medvedev, V.S., Troitsky, A.V., Bystrova, T.N. et al. Method for determining the number of aldehydes in dextran polyaldehyde using 2,4-dinitrophenylhydrazine. Pharm Chem J 46, 573–577 (2012). https://doi.org/10.1007/s11094-012-0849-2

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  • DOI: https://doi.org/10.1007/s11094-012-0849-2

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