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Antitumor activity of imidazole derivatives: dacarbazine and the new alkylating agent imidazene (Review)

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Pharmaceutical Chemistry Journal Aims and scope

The physicochemical properties and antitumor activity of dacarbazine, its analogs, and the new alkylating agent imidazene are reviewed. It is shown that the activity of dacarbazine is superior to most of its analogs. Imidazene exhibits an advantage over dacarbazine with respect to both stability and activity and can be used for the treatment of malignant melanoma and sarcoma of soft tissues and in combined chemotherapy.

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Authors and Affiliations

  1. Scientific and Technological Center of Organic and Pharmaceutical Chemistry, Yerevan, Armenia

    M. A. Iradyan, N. S. Iradyan, G. M. Stepanyan & B. T. Garibdzhanyan

  2. Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of Armenia, Yerevan, Armenia

    F. G. Arsenyan & B. T. Garibdzhanyan

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  1. M. A. Iradyan
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  2. N. S. Iradyan
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  3. G. M. Stepanyan
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  4. F. G. Arsenyan
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 44, No. 4, pp. 11 – 18, April, 2010.

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Iradyan, M.A., Iradyan, N.S., Stepanyan, G.M. et al. Antitumor activity of imidazole derivatives: dacarbazine and the new alkylating agent imidazene (Review). Pharm Chem J 44, 175–182 (2010). https://doi.org/10.1007/s11094-010-0425-6

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