Drug Synthesis Methods and Production Technologies

Pharmaceutical Chemistry Journal

, Volume 42, Issue 2, pp 95-97

First online:

Applications of extraction freezing in pharmacology and biochemistry

  • V. N. BekhterevAffiliated withSochi State University of Tourism and Recreation
  • , S. N. GavrilovaAffiliated withForensic Medicine Bureau
  • , E. V. KoshkarevaAffiliated withSochi Department, State Krasnodar Forensic Laboratory

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A method for extracting organic substances from aqueous media by combining extraction with freezing is described. The method allows hydrophilic extractants to be used. Analysis of ionogenic organic compounds provides an example demonstrating the wide potential of this method. A method for the analysis of 1,4-benzodiazepines in urine was developed. As compared with existing methods, the sample preparation procedure described here is significantly quicker and simpler, and requires virtually no laboratory equipment.