Applications of extraction freezing in pharmacology and biochemistry
Drug Synthesis Methods and Production Technologies
First Online: 10 August 2008 Received: 17 October 2006 DOI:
Cite this article as: Bekhterev, V.N., Gavrilova, S.N. & Koshkareva, E.V. Pharm Chem J (2008) 42: 95. doi:10.1007/s11094-008-0067-0 Abstract
A method for extracting organic substances from aqueous media by combining extraction with freezing is described. The method allows hydrophilic extractants to be used. Analysis of ionogenic organic compounds provides an example demonstrating the wide potential of this method. A method for the analysis of 1,4-benzodiazepines in urine was developed. As compared with existing methods, the sample preparation procedure described here is significantly quicker and simpler, and requires virtually no laboratory equipment.
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 42, No. 2, pp. 44–46, February, 2008.
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