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The Emerging Therapeutic Role of NGF in Alzheimer’s Disease

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Abstract

Alzheimer’s disease (AD) is the most common type of neurodegenerative dementia that affects the elderly population. Nerve growth factor (NGF) contributes to the survival, regeneration and death of neurons during aging and in neurodegenerative diseases. Recently, research has shown that NGF is related to the pathology, mechanisms and symptoms of AD. Therefore, there is a need to summarize the new advancements in NGF research and its potential therapeutic implications in AD. In this review, we will focus on NGF distribution, production, and function; the interaction of Aβ and NGF; and the effect of different therapy methods on AD. In summary, we hope to describe the experimental and clinical data demonstrating the important roles of NGF for AD treatment.

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Acknowledgments

This project is supported by the Zhejiang Provincial Natural Science Foundation of China (LY13H090007) and the National Natural Science Foundation of China (No. 31171033).

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    Authors and Affiliations

    1. Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University, Cha Shan, University Town, Wenzhou, 325035, Zhejiang, China

      Chao-Jin Xu

    2. Department of Clinical Laboratory, Fudan University Affiliated Huadong Hospital, Shanghai, 200040, China

      Jun-Ling Wang

    3. Institute of Nano Biomedicine and Engineering, Department of Instrument Science and Engineering, Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China

      Wei-Lin Jin

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    Chao-jin Xu and Jun-Ling Wang have contributed equally to this paper.

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    Xu, CJ., Wang, JL. & Jin, WL. The Emerging Therapeutic Role of NGF in Alzheimer’s Disease. Neurochem Res 41, 1211–1218 (2016). https://doi.org/10.1007/s11064-016-1829-9

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