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Gallic Acid Modulates Cerebral Oxidative Stress Conditions and Activities of Enzyme-Dependent Signaling Systems in Streptozotocin-Treated Rats

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Abstract

Redox imbalances and altered signaling processes in the brain are characteristic features of diabetic complications. Hence, the present study therefore sought to evaluate the effect of gallic acid (GA) on disturbed redox systems and activity of neurotransmission signaling dependent enzymes such as sodium pump, purinergic enzymes and acetylcholinesterase in diabetic animal models. We observed that GA markedly improves the antioxidant status of diabetic animals. Furthermore, the diminution of the activity of Na+/K+-ATPase and increased activities of acetylcholinesterase and the purinergic enzymes associated with diabetes progression were reversed to normalcy with the administration of GA in diabetic animals. Hence, we conclude that GA is a potential candidate in the management of neuronal dysfunction that often accompanied complications associated with diabetic hyperglycemia.

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Acknowledgments

This study was supported by grants from CAPES, FINEP, FAPERGS, PRONEX and CNPq. The authors are also thankful to the FINEP research grant ‘Rede Instituto Brasileiro de Neurociencia (IBN-Net)’ #01.06.0842-00 and the INCT for Excitotoxicity and Neuroprotection-CNPq. In addition, the work is also supported by CNPq-ProAfrica grant awarded to IJK and JBTR.

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  1. Department of Biochemistry, Federal University of Technology, Akure, Ondo State, Nigeria

    I. J. Kade

  2. Postgraduate Programme in Biochemical Toxicology, Centre of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil

    I. J. Kade & J. B. T. Rocha

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Correspondence to I. J. Kade.

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Kade, I.J., Rocha, J.B.T. Gallic Acid Modulates Cerebral Oxidative Stress Conditions and Activities of Enzyme-Dependent Signaling Systems in Streptozotocin-Treated Rats. Neurochem Res 38, 761–771 (2013). https://doi.org/10.1007/s11064-013-0975-6

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