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Regulation of Adhesion by Flexible Ectodomains of IgCAMs

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Abstract

To perform their diverse biological functions the adhesion activities of the cell adhesion molecules of the immunoglobulin superfamily (IgCAMs) might be regulated by local clustering, proteolytical shedding of their ectodomains or rapid recycling to and from the plasma membrane. Another form of regulation of adhesion might be obtained through flexible ectodomains of IgCAMs which adopt distinct conformations and which in turn modulate their adhesion activity. Here, we discuss variations in the conformation of the extracellular domains of CEACAM1 and CAR that might influence their binding and signaling activities. Furthermore, we concentrate on alternative splicing of single domains and short segments in the extracellular regions of L1 subfamily members that might affect the organization of the N-terminal located Ig-like domains. In particular, we discuss variations of the linker sequence between Ig-like domains 2 and 3 (D2 and D3) that is required for the horseshoe conformation.

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Acknowledgments

The authors’ work was supported by a grant from DFG (Ra424/5-1). The critical reading of the manuscript by Dr Alistair Garratt is greatly acknowledged.

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  1. Jadwiga Schreiber

    Present address: Department of Neuroscience, Erasmus University Medical Center, P. O. Box 2040, 3000 CA, Rotterdam, The Netherlands

Authors and Affiliations

  1. Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Markwiesenstr. 55, 72770, Reutlingen, Germany

    Hansjürgen Volkmer

  2. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13092, Berlin, Germany

    Jadwiga Schreiber & Fritz G. Rathjen

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  1. Hansjürgen Volkmer
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  2. Jadwiga Schreiber
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Correspondence to Fritz G. Rathjen.

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Special Issue: In Honor of Elisabeth Bock.

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Volkmer, H., Schreiber, J. & Rathjen, F.G. Regulation of Adhesion by Flexible Ectodomains of IgCAMs. Neurochem Res 38, 1092–1099 (2013). https://doi.org/10.1007/s11064-012-0888-9

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