Neurochemical Research

, Volume 36, Issue 3, pp 406–411

IGFBP-3 Inhibits the Proliferation of Neural Progenitor Cells

Original Paper

DOI: 10.1007/s11064-010-0349-2

Cite this article as:
Kalluri, H.S.G. & Dempsey, R.J. Neurochem Res (2011) 36: 406. doi:10.1007/s11064-010-0349-2

Abstract

Insulin like growth factor-1 (IGF-1) plays an important role in the proliferation and differentiation of neural progenitor cells. The effects of IGF-1 can be regulated by insulin like growth factor binding protein-3 (IGFBP-3) which can either inhibit or stimulate the proliferation of cells depending on the expression of proteases that can release IGF-1 from IGF1-IGFBP3 complex. Although IGF-1 is essential for the development of brain, both IGFBP-3 and IGF-1 are elevated in the brains of children younger than 6 months of age. Likewise, IGFBP-3 is also upregulated following cerebral ischemia and hypoxia. However, the role of IGFBP-3 in neurogenesis is not clear. Using an in vitro culture system of rat neural progenitor cells, we demonstrate that IGFBP-3 specifically regulates the IGF-1 mediated neural progenitor cell proliferation via down regulation of phopho-Akt, and cyclin D1. In addition, IGFBP-3 also decreased the content of nestin in the neural progenitor cells indicating its potential role in neurogenesis.

Keywords

Neural stem cellsCell cycleRetinoblastomaNeurogenesis

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Department of NeurosurgeryUniversity of WisconsinMadisonUSA
  2. 2.Department of Neurosurgery and Cardiovascular Research CenterUniversity of WisconsinMadisonUSA