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Therapeutic Strategy for Ischemic Stroke

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Abstract

Possible strategies for treating ischemic stroke include: (1) Neuroprotection: preventing damaged neurons from undergoing apoptosis in the acute phase of cerebral ischemia; (2) Stem cell therapy: the repair of broken neuronal networks with newly born neurons in the chronic phase of cerebral ischemia. Firstly, we studied the neuroprotective effect of a calcium channel blocker, azelnidipine, or a by-product of heme degradation, biliverdin, in the ischemic brain. These results revealed both azelnidipine and biliverdin had a neuroprotective effect in the ischemic brain through their anti-oxidative property. Secondly, we investigated the role of granulocyte colony-stimulating factor (G-CSF) by administering G-CSF to rats after cerebral ischemia and found G-CSF plays a critical role in neuroprotection. Lastly, we developed a restorative stroke therapy with a bio-affinitive scaffold, which is able to provide an appropriate environment for newly born neurons. In the future, we will combine these strategies to develop more effective therapies for treatment of strokes.

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Authors and Affiliations

  1. Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8558, Japan

    Toru Yamashita, Kentaro Deguchi, Yoshihide Sehara, Violeta Lukic-Panin, Hanzhe Zhang, Tatsushi Kamiya & Koji Abe

Authors
  1. Toru Yamashita
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  2. Kentaro Deguchi
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  3. Yoshihide Sehara
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  4. Violeta Lukic-Panin
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  5. Hanzhe Zhang
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  6. Tatsushi Kamiya
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  7. Koji Abe
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Corresponding author

Correspondence to Koji Abe.

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Special issue article in honor of Dr. Akitane Mori.

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Yamashita, T., Deguchi, K., Sehara, Y. et al. Therapeutic Strategy for Ischemic Stroke. Neurochem Res 34, 707–710 (2009). https://doi.org/10.1007/s11064-008-9842-2

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  • DOI: https://doi.org/10.1007/s11064-008-9842-2

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