Original Paper

Neurochemical Research

, Volume 31, Issue 11, pp 1371-1374

Induction of Transcription Factor A-myb Expression in Reactive Astrocytes Following an Excitotoxic Lesion in the Mouse Hippocampus

  • Gye Sun JeonAffiliated withDepartment of Anatomy, Seoul National University College of Medicine
  • , Hee Jine ByunAffiliated withDepartment of Anatomy, Seoul National University College of Medicine
  • , Sung Kyung ParkAffiliated withDepartment of Anatomy, Seoul National University College of Medicine
  • , Sang Wook ParkAffiliated withDepartment of Anatomy, Seoul National University College of Medicine
  • , Dong Woon KimAffiliated withDepartment of Anatomy, Seoul National University College of Medicine
  • , Je Hoon SeoAffiliated withDepartment of Anatomy, Chungbuk National University College of Medicine
  • , Choong Ik ChaAffiliated withDepartment of Anatomy, Seoul National University College of MedicineMRC Neuroscience Research Institute, Seoul National University College of Medicine
  • , Sa Sun ChoAffiliated withDepartment of Anatomy, Seoul National University College of MedicineMRC Neuroscience Research Institute, Seoul National University College of Medicine Email author 

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Abstract

In the present study, we examined patterns of A-myb expression in the kainic acid (KA)-treated mouse hippocampus. Western blot analysis revealed that A-myb expression was dramatically increased in brain 3 days after KA treatment, and was sustained for more than 7 days. A-myb immunoreactivity was restricted to hippocampal neurons in control mice. Three days after KA treatment, strong A-myb immunoreactivity was observed in reactive astrocytes throughout the CA3 region. Thereafter, A-myb immunoreactive astrocytes gradually concentrated around the CA3 region in parallel with selective neuronal loss, and only a few A-myb immunoreactive astrocytes persisted in the CA3 region 14 days after KA treatment. These findings suggest that the A-myb plays a role in the reactive gliosis signaling pathway in KA-induced excitotoxic lesions.

Keywords

A-myb Reactive astrocytes Kainic acid Hippocampus