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Cerebrospinal Fluid Catecholamine Levels in Japanese Encephalitis Patients with Movement Disorders

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Norepinephrine and dopamine have important role in movement disorders but their role in movement disorders associated with Japanese encephalitis (JE) has not been evaluated. Therefore, in the present study, cerebrospinal fluid (CSF) catecholamine levels and its metabolites in JE patients with movement disorders were compared with those without JE. CSF was collected by lumbar puncture and analyzed by HPLC-ED. Norepinephrine, dopamine and homovanillic acid concentrations were significantly (P<0.005) lower in JE patients compared to control groups. Low levels of catecholamines in JE associated movement disorders compared to idiopathic Parkinson’s disease and other extrapyramidal symptoms may be due to severe structural damage to thalamus, basal ganglia and brainstem in JE patients as revealed by MRI findings.

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References

  1. P. F. Teychenne C. R. Lake M. G. Ziegler (1980) Cerebrospinal fluid studies in Parkinson’s disease J. H. Wood (Eds) Neurobiology of cerebrospinal fluid Plenum Press New York 197–206

    Google Scholar 

  2. J. T. Turkka K. K. Juujarvi V. V. Myllyla (1987) ArticleTitleCorrelation of autonomic dysfunction to CSF concentration of noradrenaline and 3 methoxy-4 hydroxyphenyl glycol in Parkinson’s disease European. Neurol. 26 29–34 Occurrence Handle1:STN:280:BiiC3sznt1E%3D

    CAS  Google Scholar 

  3. H. Narabayashi T. Kondo T. Nagatsu A. Hayashi T. Suzuki (1984) ArticleTitledl-threo-3,4-dihydroxyphenylserine for freezing symptoms in Parkinsonism Adv. Neurol. 40 497–502 Occurrence Handle6421112 Occurrence Handle1:STN:280:BiuC38vms1Y%3D

    PubMed  CAS  Google Scholar 

  4. N. P. Quinn J. S. Perlmutter C. D. Marsden (1984) ArticleTitleAcute administration of l-threo DOPS does not affect the freezing phenomenon in parkinsonian patients Neurology 34 S149

    Google Scholar 

  5. P. R. Martin H. Weingartner E. K. Gordon R. S. Burns M. Linnoila I. J. Kopin M. H. Ebert (1984) ArticleTitleCentral nervous system catecholamine metabolism in Korsakoff’s psychosis Ann. Neurol. 15 184–187 Occurrence Handle10.1002/ana.410150212 Occurrence Handle6200058 Occurrence Handle1:STN:280:BiuC2M3lsl0%3D

    Article  PubMed  CAS  Google Scholar 

  6. M. G. Ziegler C. R. Lake J. H. Wood B. R. Brooks M. H. Ebert (1977) ArticleTitleRelationship between norepinephrine in blood and cerebrospinal fluid in the presence of a blood cerebrospinal fluid barrier for norepinephrine J. Neurochem. 28 677–679 Occurrence Handle404398 Occurrence Handle1:CAS:528:DyaE2sXkvF2gsLk%3D

    PubMed  CAS  Google Scholar 

  7. D. S. Goldstein R. Zimlichman G. D. Kelly R. Stull J. D. Bacher H. R. Keiser (1987) ArticleTitleEffect of ganglionic blockade on cerebrospinal fluid norepinerphrine J. Neurochem. 49 1484–1490 Occurrence Handle3668535 Occurrence Handle1:CAS:528:DyaL2sXmtFags7o%3D

    PubMed  CAS  Google Scholar 

  8. J. Kalita U. K. Misra (2000) ArticleTitleMarkedly severe dystonia in Japanese encephalitis Mov. Disord. 15 1168–1172 Occurrence Handle10.1002/1531-8257(200011)15:6<1168::AID-MDS1016>3.0.CO;2-V Occurrence Handle11104201 Occurrence Handle1:STN:280:DC%2BD3MzgsVahsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  9. U. K. Misra J. Kalita (1997) ArticleTitleMovement disorders in Japanese encephalitis J. Neurol. 244 299–303 Occurrence Handle9178154 Occurrence Handle1:STN:280:ByiA387ktlc%3D

    PubMed  CAS  Google Scholar 

  10. K. Kalita B. K. Das U. K. Misra (1999) ArticleTitleSPECT studies of regional cerebral blood flow in 8 patients with Japanese encephalitis in subacute and chronic stage Acta Neurol. Scand. 99 213–218 Occurrence Handle10225350 Occurrence Handle1:STN:280:DyaK1M3jvFymtA%3D%3D

    PubMed  CAS  Google Scholar 

  11. S. Fahn (1989) Assessment of primary dystonia T. L. Munset (Eds) Quantification of neurologic deficit Butterworth Boston 241–270

    Google Scholar 

  12. S. Fahn R. L. Elton (1987) Unified Parkinson’s disease rating scale S. Fahn C. D., Marsden D. S. Goldstein (Eds) Recent developments in Parkinson’s disease MacMillian New York 153–163

    Google Scholar 

  13. L. G. Chia F. C. Cheng J. S. Kuo (1993) ArticleTitleMonoamines and their metabolites in plasma and lumbar cerebrospinal fluid of Chinese patients with Parkinson’s disease J. Neurol. Sci. 116 125–134 Occurrence Handle10.1016/0022-510X(93)90316-Q Occurrence Handle8336158 Occurrence Handle1:CAS:528:DyaK3sXmt1egsLs%3D

    Article  PubMed  CAS  Google Scholar 

  14. E. Eldrup P. Mogensen J. Jacobsen H. Pakkenberg N. J. Christensen (1995) ArticleTitleCSF and plasma concentration of free norepinephrine, dopamine, 3,4-dihydroxy phenyl acetic acid (DOPAC), 3,4 dihydroxy phenyl aderanline (DOPA) and epinephrine in Parkinson’s disease Acta. Neurol. Scand. 92 116–121 Occurrence Handle7484057 Occurrence Handle1:CAS:528:DyaK2MXnsFKktLw%3D

    PubMed  CAS  Google Scholar 

  15. P. Malais A. Waltregno A. Maula A. Dresse (1990) ArticleTitleDopamine and acetylcholine release in thalamus of non-parkinsonian and parkinsonian subjects Acta Neurol. Belg. 90 200–206 Occurrence Handle2124030 Occurrence Handle1:STN:280:By6D2srpvFM%3D

    PubMed  CAS  Google Scholar 

  16. M. A. Raskind E. R. Peskind J. B. Halter D. C. Timerson (1984) ArticleTitleNorepinephrine and MHPG levels in CSF and plasma in Alzheimer’s disease Arch. Geriat. Psychiat. 41 343–346 Occurrence Handle1:STN:280:BiuC2MzhsFI%3D

    CAS  Google Scholar 

  17. H. Liu R. P. Iacono T. Schoonenberg S. Kuniyoshi J. Buchholz (1999) ArticleTitleA comparative study on neurochemistry of cerebrospinal fluid in advanced Parkinson’s disease Neurobiol. Dis. 6 35–42 Occurrence Handle10.1006/nbdi.1998.0222 Occurrence Handle10078971

    Article  PubMed  Google Scholar 

  18. U. K. Misra J. Kalita (2002) ArticleTitlePrognosis of Japanese encephalitis patients with dystonia compared to those with parkinsonian features only Postgrad. Med. J. 78 238–241 Occurrence Handle11930028 Occurrence Handle1:STN:280:DC%2BD387pslWnuw%3D%3D

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical sciences, RaeBarali Road, 226014, Lucknow, India

    U. K. Misra, J. Kalita, S. Pandey & G. Nagesh Babu

  2. Industrial Toxicology Research Centre, Lucknow, India

    V. K. Khanna

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  1. U. K. Misra
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  2. J. Kalita
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  3. S. Pandey
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  4. V. K. Khanna
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  5. G. Nagesh Babu
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Correspondence to G. Nagesh Babu.

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Misra, U.K., Kalita, J., Pandey, S. et al. Cerebrospinal Fluid Catecholamine Levels in Japanese Encephalitis Patients with Movement Disorders. Neurochem Res 30, 1075–1078 (2005). https://doi.org/10.1007/s11064-005-7414-2

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  • DOI: https://doi.org/10.1007/s11064-005-7414-2

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