We examined the relationships between the ERP measurements and concentrations of plasma monoamine metabolites in 20 healthy volunteers. Event-related potentials were recorded within the framework of two auditory paradigms, a standard oddball task and a novelty oddball task. The plasma concentrations of homovanillic acid (HVA, a metabolite of dopamine) and 3-methoxy-4-hydroxyphenylglycol (MHPG, a metabolite of noradrenaline) were analyzed. Some of the N100 measurements correlated with the MHPG concentration and the severity of anxiety. No significant correlations were found between the P300 measurements and concentrations of monoamine metabolites. The P300 latency and plasma HVA concentration were associated with the psychoticism estimate of EPQ. These findings indicate that modulation of the N100 component might be associated with the activity of the noradrenergic system, and that P300 latency and the HVA concentration might be associated with a tendency toward psychosis.
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References
J. T. Coull, “Neural correlates of attention and arousal: insights from electrophysiology, functional neuroimaging and psychopharmacology,” Prog. Neurobiol., 55, 343–361 (1998).
T. Frodl-Bauch, R. Bottlender, and U. Hegerl, “Neurochemical substrates and neuroanatomical generators of the event-related P300,” Neuropsychobiology, 40, 86–94 (1990).
J. Polich, “Clinical application of the P300 event-related brain potential,” Phys. Med. Rehabil. Clin. N. Am., 15, 133–161 (2004).
C. C. Duncan, R. J. Barry, J. F. Connolly, et al., “Eventrelated potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400,” Clin. Neurophysiol., 120, 1883–1908 (2009).
J. M. Ford, “Schizophrenia: the broken P300 and beyond,” Psychophysiology, 36, 667–682 (1999).
G. K. Thaker, “Neurophysiological endophenotypes across bipolar and schizophrenia psychosis,” Schizophr. Bull., 34, 760–773 (2008).
L. J. Siever and K. L. Davis, “The pathophysiology of schizophrenia disorders: perspectives from the spectrum,” Am. J. Psychiat., 161, 398–413 (2004).
O. Pogarell, F. Padberg, S. Karch, et al, “Dopaminergic mechanisms of target detection – P300 event-related potential and striatal dopamine,” Psychiat. Res., 194, 212–218 (2011).
R. C. Oldfield, “The assessment and analysis of handedness: the Edinburgh inventory,” Neuropsychologia, 9, 97–113 (1971).
C. D. Spielberger, R. L. Gorsuch RL, and R. E. Lushene, STAI manual, Consulting Psychologist Press, Palo Alto (1970).
H. J. Eysenck, Manual of the Eysenck Personality Questionnaire, Hoder and Stoughton, London (1975).
C. Grillon, E. Courchesne, R. Ameli, et al., “Increased distractibility in schizophrenic patients. Electrophysiologic and behavioral evidence,” Arch. Gen. Psychiat., 47, 171–179 (1990).
M. Fukuda, A. Hata, S. Niwa, et al., “Plasma vanillylmandelic acid level as an index of psychological stress response in normal subjects,” Psychiat. Res., 63, 7–16 (1996).
C. S. Herrmann and R. T. Knight, “Mechanisms of human attention: event-related potentials and oscillations,” Neurosci. Biobehav. Rev., 25, 465–476 (2001).
A. Iwanami, T. Shinba, M. Sumi, et al., “Effects of methamphetamine on auditory event-related potentials in rats. European,” Neuropsychopharmacol., 5, 103–106 (1995).
A. Iwanami, H. Isono, A. Y. Okajima, et al., “Auditory event-related potentials in panic disorder,” Eur. Arch. Psychiat. Neurosci., 247, 107–111 (1997).
M. A. Albert, M. T. Martin-Iverson, G. Price, et al., “Dexamphetamine-induced reduction of P3a and P3b in healthy participants,” J. Psychopharmacol., 25, 1623–1631 (2011).
A. Iwanami, N. Kuroki, S. Iritani, et al., “P3a of event-related potential in chronic methamphetamine dependence,” J. Nerv. Ment. Dis., 186, 746–51 (1998).
Y. Mochizuki, M. Oishi, and T. Takasu, “Correlations between P300 components and neurotransmitters in the cerebrospinal fluid,” Clin. Electroencephalogr., 29, 7–9, 1998.
J. Ito, S. Yamao, H. Fukuda, et al., “The P300 eventrelated potentials in dementia of the Alzheimer type. Correlations between P300 and monoamine metabolites,” Electroencephalogr. Clin. Neurophysiol., 77, 174–178 (1990).
M. Oishi, Y. Mochizuki, H. Yoshihashi, et al., “Laboratory examinations correlated with severity of dementia,” Ann. Clin. Lab. Sci., 26, 340–345 (1996).
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Iwanami, A., Okajima, Y., Takashio, O. et al. Event-Related Potentials and Plasma Levels of Monoamine Metabolites in Normal Subjects. Neurophysiology 44, 470–473 (2012). https://doi.org/10.1007/s11062-012-9320-y
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DOI: https://doi.org/10.1007/s11062-012-9320-y