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Clinical features and prognostic factors of WHO II and III adult spinal meningiomas: analysis of 25 cases in a single center

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Abstract

Spinal World Health Organization (WHO) II and III meningiomas are relatively rare, and often associated with great clinical aggressiveness and poor overall survival. There are controversies over factors affecting the prognosis of this disease. The aim of this retrospective study was to evaluate factors that may affect the therapeutic outcome and prognosis of adult high-grade spinal meningiomas by reviewing the medical records of 25 patients who were surgically treated in our hospital between 2001 and 2014. Univariate and multivariate analyses were performed to identify prognostic variables relative to patient and tumor characteristics, and treatment modalities. All 25 patients (14 men and 11 women; mean age 46.6 ± 16.1 years) underwent surgical resection. Local recurrence was occurred in 13 (52.0 %) patients, and 10 (40.0 %) patients died during the follow-up periods. The 5-year recurrence rate was 60.0 % and the 5-year survival rate was 68.0 %. The results of statistical analysis suggested that Simpson resection grade and the number of involved segments were prognostic factors related to progression-free survival and that sex, age, preoperative Frankel score, the number of involved segments and WHO grade were closely correlated with survival. Furthermore, we confirmed that the number of involved segments was the major independent factor affecting recurrence of patients with adult spinal high-grade meningiomas, and that sex, age and WHO grade were prognostic factors affecting survival but not recurrence.

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Acknowledgments

This study was supported by the Research Projects of Science and Technology Commission of Shanghai Municipality, China (13ZR1414200 ) and Research Projects of Health and Family planning Commission of Shanghai Municipality, China (2013210).

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    Authors and Affiliations

    1. Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai, 200003, China

      Jingliang Ye, Guoguang Lv, Jun Qian, Junle Zhu & Chun Luo

    2. Department of Neurosurgery, CPLA No. 98 Hospital, Huzhou, 313000, China

      Jingliang Ye & Ruizhang Han

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    1. Jingliang Ye
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    2. Guoguang Lv
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    3. Jun Qian
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    Correspondence to Ruizhang Han or Chun Luo.

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    The authors declare no competing conflicts of interest.

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    Jingliang Ye, Guoguang Lv and Jun Qian contributed equally to this work, and all should be considered first author.

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    Ye, J., Lv, G., Qian, J. et al. Clinical features and prognostic factors of WHO II and III adult spinal meningiomas: analysis of 25 cases in a single center. J Neurooncol 128, 349–356 (2016). https://doi.org/10.1007/s11060-016-2119-8

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    • DOI: https://doi.org/10.1007/s11060-016-2119-8

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