Abstract
To provide radiobiological information on the inherent response of intracranial meningiomas after three-dimensional conformal radiation therapy. Quantitative tumor volume measurements were generated from 120 magnetic resonance images of a total of 24 patients. Gross tumor volumes were delineated on a series of contrast-enhanced T1-weighted magnetic resonance images by using commercial software. The percentage of tumor volume reduction at each follow-up was determined and compared to the baseline tumor volume. The median follow-up time was 103.5 months (range 30–137 months). The mean pre-radiation therapy tumor volume was 30.0 cm3 (range 1.3–167.4 cm3). Tumor volume reduction was observed in 96 % of the study population. The mean absolute and relative tumor volume reduction were 14.0 cm3 (range −0.6–84.5 cm3) and 40.8 % (range −6.8–82.9 %), respectively. The mean relative tumor volume reduction was 15.9, 28.9, 40.5, 50.3, and 52.6 % at 2, 4, 6, 8, and 10 years after irradiation. The quantitative volumetric analysis of the pattern of tumor volume reduction in response to irradiation gives an insight into the radiobiological nature of intracranial meningiomas after conventionally fractionated radiation therapy.
Similar content being viewed by others
References
Vernimmen FJ, Harris JK, Wilson JA, Melvill R, Smit BJ, Slabbert JP (2001) Stereotactic proton beam therapy of skull base meningiomas. Int J Radiat Oncol Biol Phys 49:99–105
Shrieve DC, Hazard L, Boucher K, Jensen RL (2004) Dose fractionation in stereotactic radiotherapy for parasellar meningiomas: radiobiological considerations of efficacy and optic nerve tolerance. J Neurosurg 101(Suppl 3):390–395. doi:10.3171/jns.2004.101.supplement3.0390
Vernimmen FJ, Slabbert JP (2010) Assessment of the alpha/beta ratios for arteriovenous malformations, meningiomas, acoustic neuromas, and the optic chiasma. Int J Radiat Biol 86:486–498. doi:10.3109/09553001003667982
Henzel M, Gross MW, Hamm K, Surber G, Kleinert G, Failing T, Strassmann G, Engenhart-Cabillic R (2006) Significant tumor volume reduction of meningiomas after stereotactic radiotherapy: results of a prospective multicenter study. Neurosurgery 59:1188–1194. doi:10.1227/01.NEU.0000245626.93215.F6 discussion 1194
Feigl GC, Samii M, Horstmann GA (2007) Volumetric follow-up of meningiomas: a quantitative method to evaluate treatment outcome of gamma knife radiosurgery. Neurosurgery 61:281–286. doi:10.1227/01.NEU.0000279999.95953.EA discussion 286–287
Astner ST, Theodorou M, Dobrei-Ciuchendea M, Auer F, Kopp C, Molls M, Grosu AL (2010) Tumor shrinkage assessed by volumetric MRI in the long-term follow-up after stereotactic radiotherapy of meningiomas. Strahlenther Und Onkol 186:423–429. doi:10.1007/s00066-010-2138-x
Mozley PD, Bendtsen C, Zhao B, Schwartz LH, Thorn M, Rong Y, Zhang L, Perrone A, Korn R, Buckler AJ (2012) Measurement of tumor volumes improves RECIST-based response assessments in advanced lung cancer. Transl Oncol 5:19–25
Welsh JL, Bodeker K, Fallon E, Bhatia SK, Buatti JM, Cullen JJ (2012) Comparison of response evaluation criteria in solid tumors with volumetric measurements for estimation of tumor burden in pancreatic adenocarcinoma and hepatocellular carcinoma. Am J Surg 204:580–585. doi:10.1016/j.amjsurg.2012.07.007
Lee JY, Niranjan A, McInerney J, Kondziolka D, Flickinger JC, Lunsford LD (2002) Stereotactic radiosurgery providing long-term tumor control of cavernous sinus meningiomas. J Neurosurg 97:65–72. doi:10.3171/jns.2002.97.1.0065
DiBiase SJ, Kwok Y, Yovino S, Arena C, Naqvi S, Temple R, Regine WF, Amin P, Guo C, Chin LS (2004) Factors predicting local tumor control after gamma knife stereotactic radiosurgery for benign intracranial meningiomas. Int J Radiat Oncol Biol Phys 60:1515–1519. doi:10.1016/j.ijrobp.2004.05.073
Kreil W, Luggin J, Fuchs I, Weigl V, Eustacchio S, Papaefthymiou G (2005) Long term experience of gamma knife radiosurgery for benign skull base meningiomas. J Neurol Neurosurg Psychiatry 76:1425–1430. doi:10.1136/jnnp.2004.049213
Kollova A, Liscak R, Novotny J Jr, Vladyka V, Simonova G, Janouskova L (2007) Gamma knife surgery for benign meningioma. J Neurosurg 107:325–336. doi:10.3171/JNS-07/08/0325
Zada G, Pagnini PG, Yu C, Erickson KT, Hirschbein J, Zelman V, Apuzzo ML (2010) Long-term outcomes and patterns of tumor progression after gamma knife radiosurgery for benign meningiomas. Neurosurgery 67:322–328. doi:10.1227/01.NEU.0000371974.88873.15 discussion 328–329
Larson DA, Flickinger JC, Loeffler JS (1993) The radiobiology of radiosurgery. Int J Radiat Oncol Biol Phys 25:557–561
Metellus P, Regis J, Muracciole X, Fuentes S, Dufour H, Nanni I, Chinot O, Martin PM, Grisoli F (2005) Evaluation of fractionated radiotherapy and gamma knife radiosurgery in cavernous sinus meningiomas: treatment strategy. Neurosurgery 57:873–886 discussion 873–886
Oya S, Sade B, Lee JH (2011) Benefits and limitations of diameter measurement in the conservative management of meningiomas. Surg Neurol Int 2:158. doi:10.4103/2152-7806.89857
Conflict of interest
The authors have no conflicts of interest or financial or personal relationships with other people or organizations that could inappropriately influence this work.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lee, N.K., Kim, C.Y., Yoon, W.S. et al. Quantitative analysis of tumor volume reduction after three-dimensional conformal radiation therapy for intracranial meningiomas. J Neurooncol 121, 195–199 (2015). https://doi.org/10.1007/s11060-014-1625-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11060-014-1625-9