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Atypical meningoma: current management dilemmas and prospective clinical trials

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Abstract

Atypical meningioma is an intermediate grade tumour with a greater risk of recurrence following surgical resection. Changes to the WHO classification have resulted in an increased reporting of these tumours. The role of early adjuvant radiotherapy after gross total resection has not been clearly defined and the literature evidence is of poor quality providing conflicting information. This review assesses the evidence for current clinical practice, management dilemmas and the need for prospective clinical trials for atypical meningioma.

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Conflict of interest

MDJ, BJH, CLM and MJ are recipients of a £1.37 m Grant for the ROAM trial from the NIHR-HTA programme. DCW is the lead investigator for the EORTC collaborative group.

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Authors and Affiliations

  1. Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, L9 7LJ, UK

    Michael D. Jenkinson & Rasheed Zakaria

  2. Institute of Infection and Global Health, University of Liverpool, Liverpool, L69 7BE, UK

    Michael D. Jenkinson & Conor L. Mallucci

  3. Center for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland

    Damien C. Weber

  4. University of Bern, Bern, Switzerland

    Damien C. Weber

  5. Department of Radiation Oncology, Clatterbridge Cancer Centre, Wirral, 63 4YJ, UK

    Brian J. Haylock

  6. Department of Paediatric Neurosurgery, Alder Hey Children’s Hospital, Liverpool, L12 2AP, UK

    Conor L. Mallucci

  7. Department of Neurosurgery, Beaumont Hospital, Dublin 9, Ireland

    Mohsen Javadpour

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  1. Michael D. Jenkinson
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  3. Brian J. Haylock
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Correspondence to Michael D. Jenkinson.

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Jenkinson, M.D., Weber, D.C., Haylock, B.J. et al. Atypical meningoma: current management dilemmas and prospective clinical trials. J Neurooncol 121, 1–7 (2015). https://doi.org/10.1007/s11060-014-1620-1

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  • DOI: https://doi.org/10.1007/s11060-014-1620-1

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