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The survival of patients with high grade glioma from different ethnic groups in South East England

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An Erratum to this article was published on 08 October 2014

Abstract

Studies in the United States (US) have reported varying treatment and survival for patients with high grade glioma from different ethnic groups. This study investigates for the first time whether differences also exist in the United Kingdom (UK). This population-based cohort study used cancer registration data for 4,845 patients diagnosed in South East England between 2000 and 2009. Linked self-assigned ethnicity data within Hospital Episode Statistics were used to define White, Indian, Pakistani, Bangladeshi, Black Caribbean, Black African, Other and Not known groups. Logistic regression was used to generate odds ratios for a record of receipt of treatment (surgery, radiotherapy and chemotherapy), adjusting for sex, age, morphology, socioeconomic deprivation and comorbidity in each ethnic group. Hazard ratios were generated using Cox regression, adjusting for sex, age, morphology, socioeconomic deprivation, comorbidity and treatment. The overall one-year survival was 28.4 %. Ethnicity data was available for 3,793 (78 %) patients. Receipt of treatment was generally similar between different ethnic groups after adjustment for sex, age, morphology, socioeconomic deprivation and comorbidity. After adjustment for potential confounders, the Indian (HR 0.72, p = 0.037) and Other groups (HR 0.76, p = 0.003) had better survival, while the Not known group (HR 1.34, p < 0.0001) had worse survival than the White group. Patients from UK Indian groups have better survival than White patients while those from Black ethnic groups appear to have similar survival to White patients. These findings suggest the need to investigate possible contributing factors including the completeness of follow-up, clinical performance status and tumour biology.

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References

  1. Quinn M, Babb P, Brock A, Kirby L, Jones J (2001) Cancer trends in England and Wales 1950–1999. Studies in medical and population subjects. London

  2. Burnet NG, Jefferies SJ, Benson RJ, Hunt DP, Treasure FP (2005) Years of life lost (YLL) from cancer is an important measure of population burden–and should be considered when allocating research funds. Br J Cancer 92:241–245. doi:10.1038/sj.bjc.6602321

    CAS  PubMed Central  PubMed  Google Scholar 

  3. Cancer Research UK (2012) Brain and CNS Tumour Survival Statistics. http://www.cancerresearchuk.org/cancer-info/cancerstats/types/brain/survival/#one. Accessed on 11 Feb 2014

  4. McKinney PA (2004) Brain tumours: incidence, survival, and aetiology. J Neurol Neurosurg Psychiatry 75(Suppl 2):ii12-7

    PubMed  Google Scholar 

  5. Goggins WB, Wong G (2009) Cancer among Asian Indians/Pakistanis living in the United States: low incidence and generally above average survival. Cancer Causes Control 20:635–643. doi:10.1007/s10552-008-9275-x

    Article  PubMed  Google Scholar 

  6. Surawicz TS, McCarthy BJ, Kupelian V, Jukich PJ, Bruner JM, Davis FG (1999) Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990-1994. Neuro Oncol 1:14–25

    CAS  PubMed Central  PubMed  Google Scholar 

  7. Winter H, Cheng KK, Cummins C, Maric R, Silcocks P, Varghese C (1999) Cancer incidence in the south Asian population of England (1990-92). Br J Cancer 79:645–654. doi:10.1038/sj.bjc.6690102

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. National Cancer Intelligence Network (2009) Cancer Incidence and Survival by Major Ethnic Group.http://www.ncin.org.uk/view?rid=75. Accessed on 11 Feb 2014

  9. Robertson JT, Gunter BC, Somes GW (2002) Racial differences in the incidence of gliomas: a retrospective study from Memphis, Tennessee. Br J Neurosurg 16:562–566

    Article  CAS  PubMed  Google Scholar 

  10. Deorah S, Lynch CF, Sibenaller ZA, Ryken TC (2006) Trends in brain cancer incidence and survival in the United States: surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus 20:E1. doi:10.3171/foc.2006.20.4.E1

    Article  PubMed  Google Scholar 

  11. Barnholtz-Sloan JS, Sloan AE, Schwartz AG (2003) Racial differences in survival after diagnosis with primary malignant brain tumor. Cancer 98:603–609. doi:10.1002/cncr.11534

    Article  PubMed  Google Scholar 

  12. Barnholtz-Sloan JS, Maldonado JL, Williams VL, Curry WT, Rodkey EA, Barker FG 2nd, Sloan AE (2007) Racial/ethnic differences in survival among elderly patients with a primary glioblastoma. J Neurooncol 85:171–180. doi:10.1007/s11060-007-9405-4

    Article  PubMed  Google Scholar 

  13. Brain Tumour UK (2009) Register my tumour, recognise me. A special report from Brain Tumour UK. http://www.braintumouruk.org.uk/sites/default/files/register_tumours_web_ed.pdf. Accessed on 11 Feb 2014

  14. Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40:373–383

    Article  CAS  PubMed  Google Scholar 

  15. Quan H, Sundararajan V, Halfon P, Fong A, Burnand B, Luthi JC, Saunders LD, Beck CA, Feasby TE, Ghali WA (2005) Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care 43:1130–1139

    Article  PubMed  Google Scholar 

  16. Noble M, McLennan D, Wilkinson K et al (2008) The english indices of deprivation 2007. Department for Communities and Local Government, London

  17. Jack R, Davies E, Møller H (2011) Lung cancer incidence and survival in different ethnic groups in South East England. Br J Cancer 105:1049–1053

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Chen P, Aldape K, Wiencke JK, Kelsey KT, Miike R, Davis RL, Liu J, Kesler-Diaz A, Takahashi M, Wrensch M (2001) Ethnicity delineates different genetic pathways in malignant glioma. Cancer Res 61:3949–3954

    CAS  PubMed  Google Scholar 

  19. Wiencke JK, Aldape K, McMillan A, Wiemels J, Moghadassi M, Miike R, Kelsey KT, Patoka J, Long J, Wrensch M (2005) Molecular features of adult glioma associated with patient race/ethnicity, age, and a polymorphism in O6-methylguanine-DNA-methyltransferase. Cancer Epidemiol Biomark Prev 14:1774–1783

    Article  CAS  Google Scholar 

  20. Curry WT Jr, Barker FG II (2009) Racial, ethnic and socioeconomic disparities in the treatment of brain tumors. J Neurooncol 93:25–39

    Article  PubMed  Google Scholar 

  21. Prasad S, Gupta SC, Tyagi AK, Aggarwal BB (2014) Curcumin, a component of golden spice: from bedside to bench and back. Biotechnol Adv. doi:10.1016/j.biotechadv.2014.04.004

    PubMed  Google Scholar 

  22. Du WZ, Feng Y, Wang XF, Piao XY, Cui YQ, Chen LC, Lei XH, Sun X, Liu X, Wang HB, Li XF, Yang DB, Sun Y, Zhao ZF, Jiang T, Li YL, Jiang CL (2013) Curcumin suppresses malignant glioma cells growth and induces apoptosis by inhibition of SHH/GLI1 signaling pathway in vitro and vivo. CNS Neurosci Ther 19:926–936. doi:10.1111/cns.12163

    Article  CAS  PubMed  Google Scholar 

  23. Zanotto-Filho A, Braganhol E, Edelweiss MI, Behr GA, Zanin R, Schroder R, Simoes-Pires A, Battastini AM, Moreira JC (2012) The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma. J Nutr Biochem 23:591–601. doi:10.1016/j.jnutbio.2011.02.015

    Article  CAS  PubMed  Google Scholar 

  24. Zanotto-Filho A, Coradini K, Braganhol E, Schroder R, de Oliveira CM, Simoes-Pires A, Battastini AM, Pohlmann AR, Guterres SS, Forcelini CM, Beck RC, Moreira JC (2012) Curcumin-loaded lipid-core nanocapsules as a strategy to improve pharmacological efficacy of curcumin in glioma treatment. Eur J Pharm Biopharm. doi:10.1016/j.ejpb.2012.10.019

    PubMed  Google Scholar 

  25. Pobereskin LH, Chadduck JB (2000) Incidence of brain tumours in two English counties: a population based study. J Neurol Neurosurg Psychiatry 69:464–471

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Bullard J, Coleman MP, Robinson D, Lutz JM, Bell J, Peto J (2000) Completeness of cancer registration: a new method for routine use. Br J Cancer 82:1111–1116. doi:10.1054/bjoc.1999.1048

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  27. Eastern Cancer Registration and Information Centre (2010) Analysis of the cancer registry combined database for use with the Brain and CNS Registry http://www.ncin.org.uk/cancer_type_and_topic_specific_work/cancer_type_specific_work/central_nervous_system_cancers. Accessed on 11 Feb 2014

  28. Nicoll A, Bassett K, Ulijaszek SJ (1986) What’s in a name? Accuracy of using surnames and forenames in ascribing Asian ethnic identity in English populations. J Epidemiol Community Health 40:364–368

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

This study was carried out by the former Thames Cancer Registry, which received funding from the Department of Health. The views expressed in the publication are those of the authors and not necessarily those of the Department of Health. The study was completed with the support of the London Knowledge and Intelligence Team, Public Health England.

Conflict of interest

The authors have no conflict of interest to disclose.

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Authors and Affiliations

  1. Cancer Epidemiology and Population Health, Research Oncology, King’s College London, 3rd Floor, Bermondsey Wing, Guy’s Campus, London, SE1 9RT, UK

    T. Ratneswaren & E. A. Davies

  2. Public Health England, London Knowledge and Intelligence Team, 2nd Floor, Skipton House, Section C, 80 London Road, London, SE1 6HL, UK

    R. M. Jack, D. Tataru & E. A. Davies

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  1. T. Ratneswaren
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Correspondence to T. Ratneswaren.

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Ratneswaren, T., Jack, R.M., Tataru, D. et al. The survival of patients with high grade glioma from different ethnic groups in South East England. J Neurooncol 120, 531–536 (2014). https://doi.org/10.1007/s11060-014-1582-3

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  • DOI: https://doi.org/10.1007/s11060-014-1582-3

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