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Stereotactic radiosurgery compared with external radiation therapy as a primary treatment in spine metastasis from renal cell carcinoma: a multicenter, matched-pair study

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Abstract

The aim of this multicenter, matched- pair study was to compare the outcome of stereotactic radiosurgery (SRS) with that of external radiation therapy (RT) when used as a primary treatment in spine metastasis from renal cell carcinoma (RCC). From 2005 to 2012, 13 patients underwent SRS as a primary treatment in spine metastasis from RCC. Thirteen patients who underwent RT as the primary treatment of RCC spine metastasis were paired with the SRS patients based on age, number of spine metastasis, time interval from original tumor diagnosis to spine metastasis, Eastern Cooperative Oncology Group status, and year of treatment. The primary outcomes of interest were pain relief and progression free survival. Secondary outcomes were treatment toxicities and need for further treatment. The perioperative VAS score decrease was larger in the SRS group than that in the RT group (P = 0.04). More SRS patients had complete or partial pain relief although the difference was not significant. There was a significant difference in progression free survival between the two groups (P = 0.01). The percentage of patients with toxicities was 38.5 % (5/13) in the SRS group and 53.9 % (7/13) in the RT group, but the difference was not significant. There were 2 SRS patients and 3 RT patients who received further intervention at the index segment. This study showed that, when performed as a primary treatment in spine metastasis from RCC, SRS provides relatively better pain relief and better local control than that obtained from RT.

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Acknowledgments

This work was partly supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2010-0028631) and was completed as a part of research project funded by the National Evidence-based Healthcare Collaborating Agency in South Korea (No. NECA-A-13-006).

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The authors have no personal financial or institutional interest in any of the drugs, materials, or devices described in this article.

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Authors and Affiliations

  1. Department of Neurosurgery, Seoul National University College of Medicine, 101 Daehak-no, Jongno-gu, Seoul, 110-744, Korea

    Seil Sohn & Chun Kee Chung

  2. Neuroscience Research Institute, Seoul National University Medical Research Center, Seoul, Korea

    Seil Sohn & Chun Kee Chung

  3. Clinical Research Institute, Seoul National University Hospital, Seoul, Korea

    Seil Sohn & Chun Kee Chung

  4. Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Korea

    Chun Kee Chung

  5. Department of Neurosurgery, Ilsan Paik Hospital, College of Medicine, Inje University, Seoul, Korea

    Moon Jun Sohn

  6. Department of Neurosurgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Science, Seoul, Korea

    Ung-Kyu Chang

  7. Department of Radiation Oncology, St. Vincent’s Hospital, School of Medicine, The Catholic University of Korea, Seoul, Korea

    Sung Hwan Kim

  8. Department of Nursing, College of Medicine, Chosun University, Gwanju, Korea

    Jinhee Kim

  9. National Evidence-based Healthcare Collaborating Agency, Seoul, Korea

    Eunjung Park

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  1. Seil Sohn
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  2. Chun Kee Chung
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  3. Moon Jun Sohn
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  4. Ung-Kyu Chang
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  6. Jinhee Kim
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  7. Eunjung Park
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Correspondence to Chun Kee Chung.

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Sohn, S., Chung, C.K., Sohn, M.J. et al. Stereotactic radiosurgery compared with external radiation therapy as a primary treatment in spine metastasis from renal cell carcinoma: a multicenter, matched-pair study. J Neurooncol 119, 121–128 (2014). https://doi.org/10.1007/s11060-014-1455-9

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  • DOI: https://doi.org/10.1007/s11060-014-1455-9

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