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99mTc-Tetrofosmin brain SPECT in the assessment of meningiomas—correlation with histological grade and proliferation index

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Abstract

Meningiomas account for about 30% of all intracranial tumors. Evaluation of their proliferation rate is useful for assessing their biological behavior. We evaluated prospectively whether 99mTc-Tetrofosmin (99mTc-TF) uptake in meningiomas correlates with cellular proliferative activity and with tumor grade. We prospectively studied 18 meningioma cases. Brain single-photon emission computed tomography (SPECT) by 99mTc-TF was performed within a week prior to surgical excision. In the excised tumor specimens we assessed Ki-67 antigen expression. 14 of 18 patients had benign meningiomas, while the remaining four had anaplastic meningiomas. A significant correlation was found between both 99mTc-TF uptake and tumor grade (r = 0.722, P = 0.001) and between 99mTc-TF uptake and Ki-67 expression (r = 0.930, P < 0.001). There was a significant correlation between the intensity of tracer uptake and tumor recurrence at 1 year postoperative (r = 0.574, P = 0.02). This pilot study implies that 99mTc-TF brain SPECT could prove useful in differentiating benign from anaplastic meningiomas and is a potential indicator of their proliferative activity.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University of Ioannina School of Medicine, P.O. Box 103, Neohoropoulo, Ioannina, 455 00, Greece

    Andreas D. Fotopoulos, Athanasios Papadopoulos & Spyridon Tsiouris

  2. Department of Neurosurgery, University of Ioannina School of Medicine, P.O. Box 103, Neohoropoulo, Ioannina, 455 00, Greece

    George A. Alexiou, Konstantinos S. Polyzoidis & Spyridon Voulgaris

  3. Department of Pathology, University of Ioannina School of Medicine, P.O. Box 103, Neohoropoulo, Ioannina, 455 00, Greece

    Ann Goussia

  4. Department of Neurology, University of Ioannina School of Medicine, P.O. Box 103, Neohoropoulo, Ioannina, 455 00, Greece

    Athanasios P. Kyritsis

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  1. Andreas D. Fotopoulos
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  2. George A. Alexiou
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Correspondence to George A. Alexiou.

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Fotopoulos, A.D., Alexiou, G.A., Goussia, A. et al. 99mTc-Tetrofosmin brain SPECT in the assessment of meningiomas—correlation with histological grade and proliferation index. J Neurooncol 89, 225–230 (2008). https://doi.org/10.1007/s11060-008-9611-8

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  • DOI: https://doi.org/10.1007/s11060-008-9611-8

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