Laboratory Investigation

Journal of Neuro-Oncology

, Volume 72, Issue 2, pp 103-106

Aberrant TP53 protein accumulation in the neuronal component of ganglioglioma

  • Takao FukushimaAffiliated withDepartment of Neurological Surgery, Nihon University School of Medicine Email author 
  • , Yoichi KatayamaAffiliated withDepartment of Neurological Surgery, Nihon University School of Medicine
  • , Takao WatanabeAffiliated withDepartment of Neurological Surgery, Nihon University School of Medicine
  • , Atsuo YoshinoAffiliated withDepartment of Neurological Surgery, Nihon University School of Medicine
  • , Chiaki KomineAffiliated withDepartment of Neurological Surgery, Nihon University School of Medicine
  • , Takakazu YokoyamaAffiliated withDepartment of Neurological Surgery, Nihon University School of Medicine

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Abstract

Gangliogliomas are characterized by their different phenotypic composition of ganglion cells and glial cells. In contrast to the glial cells that are capable of mitotic activity, the ganglion cells are generally considered to lack a neoplastic nature. The authors report here the first unequivocal case of a ganglioglioma harboring aberrant TP53 product that was expressed predominantly in the neuronal component. GeneChip TP53 assay revealed a point mutation resulting in an exchange of amino acid. This case suggests that ganglion cells can participate in the neoplastic process of gangliogliomas.

Keywords

ganglioglioma ganglion cells glial cells mutation protein accumulation TP53 gene