Journal of Neuro-Oncology

, Volume 72, Issue 2, pp 103–106

Aberrant TP53 protein accumulation in the neuronal component of ganglioglioma

  • Takao Fukushima
  • Yoichi Katayama
  • Takao Watanabe
  • Atsuo Yoshino
  • Chiaki Komine
  • Takakazu Yokoyama
Laboratory Investigation

DOI: 10.1007/s11060-004-3549-2

Cite this article as:
Fukushima, T., Katayama, Y., Watanabe, T. et al. J Neurooncol (2005) 72: 103. doi:10.1007/s11060-004-3549-2

Abstract

Gangliogliomas are characterized by their different phenotypic composition of ganglion cells and glial cells. In contrast to the glial cells that are capable of mitotic activity, the ganglion cells are generally considered to lack a neoplastic nature. The authors report here the first unequivocal case of a ganglioglioma harboring aberrant TP53 product that was expressed predominantly in the neuronal component. GeneChip TP53 assay revealed a point mutation resulting in an exchange of amino acid. This case suggests that ganglion cells can participate in the neoplastic process of gangliogliomas.

Keywords

gangliogliomaganglion cellsglial cellsmutationprotein accumulationTP53 gene

Copyright information

© Springer 2005

Authors and Affiliations

  • Takao Fukushima
    • 1
  • Yoichi Katayama
    • 1
  • Takao Watanabe
    • 1
  • Atsuo Yoshino
    • 1
  • Chiaki Komine
    • 1
  • Takakazu Yokoyama
    • 1
  1. 1.Department of Neurological SurgeryNihon University School of MedicineItabashi-kuJapan