Intramuscular administration of the minimum effective doses (MED) of the central analgesics fentanyl and Analgin [translator’s note: metamizole], the NMDA receptor polyamine site agonist spermine, and IEM-1460, an AMPA receptor blocker and agonist of the NMDA receptor polyamine site, induced maximal analgesic effects in the tailflick test in rats. Combined intramuscular administration of Analgin and IEM-1460 and spermine at threshold doses inactive when given alone (1/5 MED) allowed the MED of Analgin to be reduced by a factor of 120 when given in combination with IEM-1460 and by a factor of 10 when given in combination with spermine. Combined intramuscular administration of fentanyl with IEM-1460 and spermine at these threshold doses decreased the MED of fentanyl by a factor of 150 when used with IEM-1460 and a factor of 15 when used with spermine.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 99, No. 12, pp. 1361–1365, December, 2013.
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Serdyuk, S.E., Gmiro, V.E. IEM-1460 and Spermine Potentiate the Analgesic Actions of Fentanyl and Analgin in Rats. Neurosci Behav Physi 45, 680–683 (2015). https://doi.org/10.1007/s11055-015-0128-2
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DOI: https://doi.org/10.1007/s11055-015-0128-2