Skip to main content

Advertisement

SpringerLink
Log in

Characteristics of the formation of systems activity in the brain and autonomic functions in children in conditions of the European North (discussion paper)

  • Published:
Neuroscience and Behavioral Physiology Aims and scope Submit manuscript

Abstract

Results obtained from complex medical-physiological investigations performed during 10 scientific expeditions in the Arkhangel’sk Region in 2003–2005 are presented. The effects of climatological-geographic, biogeochemical, and social conditions of the conditions obtaining in the Far North region of Russia on sexual maturation, formation of the structural-functional organization of the brain, autonomic functions, and immunological and biochemical status of schoolchildren were studied using state-of-the-art neurophysiological methods (computerized electroencephalography, computerized rheoencephalography, computerized electric dipole origin tomography, etc.), psychophysiological and psychometric methods (assessment of the state of cognitive and memory functions, Wechsler intellectual scale), along with biochemical assay of monoamine oxidase (MAO, the key enzyme in adrenergic neurotransmitter metabolism) and the liver enzyme butyrylcholinesterase (BuChE) and physicochemical analysis of the levels of macroelements and trace elements in the body.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. A. V. Artemenko and T. A. Kudryakova, “Psychophysiological measures of the success of educational activity in 10-year-old children living in the Far North,” in: Neurophysiological Basis of the Formation of Mental Functions in Normal and Anomalous Anatomical Development [in Russian], Moscow (1995), pp. 10–14.

  2. M. M. Bezrukikh and E. S. Loginova, “Age-related dynamics and characteristics of formation of the psychophysiological structure of the intellect in school starters with different levels of learning success,” Fiziol. Cheloveka, 32, No. 1, 15–25 (2006).

    PubMed  CAS  Google Scholar 

  3. S. S. Bekshaev, “Computer program ‘3DLocEEG’: three-dimensional localization of electrical sources in the brain generating the temporospatial profile of the electroencephalogram,” State Registration No. 2002611116, 2 July 2002.

  4. N. P. Bekhtereva, Neurophysiological Aspects of Human Mental Activity [in Russian], Nauka, Leningrad (1974).

    Google Scholar 

  5. E. R. Boiko, Physiological-Biochemical Bases of Human Activity in the North [in Russian], Urals Branch, Russian Academy of Sciences, Ekaterinburg (2005).

    Google Scholar 

  6. V. A. Vasil’eva, “Structural transformations of the visual cortex in the human brain during ontogenesis,” in: New Studies in Age-Related Physiology [in Russian], Pedagogika, Moscow (1986), Vol. 2, No. 27, pp. 32–37.

    Google Scholar 

  7. Yu. P. Gichev, Current Questions in Ecological Medicine [in Russian], Novosibirsk (1999).

  8. V. Z. Gorkin, Amine Oxidases and Their Importance in Medicine [in Russian], Meditsina, Moscow (1981).

    Google Scholar 

  9. State Report on the State of Health of the Population of the Russian Federation in 2002 [in Russian], Geogar. Med., Moscow (2003).

  10. N. I. Gurova, “Structure of the associative area of the cerebral cortex during ontogenesis,” in: New Studies in Age-Related Physiology [in Russian], Pedagogika, Moscow (1986), Vol. 2, No. 27, pp. 37–40.

    Google Scholar 

  11. A. D. Gur’yanova and A. Yu. Budantsev, “Monoamine oxidase,” Usp. Sovrem. Biol., 79, No. 2, 184–204 (1975).

    CAS  Google Scholar 

  12. L. K. Dobrodeeva and L. V. Sen’kova, “The state of the immune system in the North,” in: Questions in Human Ecology [in Russian], Northern Medical University, Arkhangel’sk (2000), pp. 69–76.

    Google Scholar 

  13. V. G. Evdokimov and A. T. Ketkin, “Seasonal changes in cardiorespiratory measures in humans in the North,” Fiziol. Cheloveka, 8, No. 3, 481–488 (1982).

    Google Scholar 

  14. N. N. Zislina, “Characteristics of brain electrical activity in children with delayed development and cerebroasthenic syndrome,” in: Children with Delayed Development [in Russian], Moscow (1971), pp. 109–121.

  15. R. F. Il’icheva and V. Z. Gorkin, “Estimation of monoamine oxidase activity in human serum,” Lab. Delo, 9, 534–536 (1979).

    PubMed  Google Scholar 

  16. I. P. Kiseleva, “Increased monoamine oxidase activity in the rat brain on exposure to lithium in vitro,” Vopr. Med. Khim., 17, No. 5, 502–505 (1972).

    Google Scholar 

  17. G. I. Kozinets, Studies of the Blood System in Immunological Practice [in Russian], Meditsina, Moscow (1987).

    Google Scholar 

  18. R. V. Kubasov, D. B. Demin, E. V. Tipisova, and A. V. Tkachev, “Hormonal support of the hypophysis-thyroid-gonad axis during sexual maturation in boys living in the Konoshskii Area of the Arkhangel’sk Region,” Zh. Ékol. Chel., 1, No. 4, 265–268 (2004).

    Google Scholar 

  19. T. A. Kudryakova, “Dynamics of EEG measures in children of school age in response to school study,” Fiziol. Cheloveka, 17, No. 1, 172–175 (1991).

    Google Scholar 

  20. C. N. Moralev, V. P. Nesterov, and O. V. Yagodina, “Structure and mechanism of action of inhibitors of neurotransmitter metabolic enzymes,” Neirokhimiya, 13, No. 3, 168–178 (1996).

    Google Scholar 

  21. L. A. Novikova and D. A. Farber, Functional Maturation of the Cortex and Subcortical Structures at Different Time Points: EEG Studies [in Russian], Nauka, Leningrad (1975).

    Google Scholar 

  22. The Sanitary-Epidemiological Situation in the Arkhangel’sk Region in 2003. Regional Report. Arkhangel’sk. Arkhangel’sk Regional Federal State of Sanitation and Epidemiological Monitoring Center, Ministry of Health of the Russian Federation, Arkhangel’sk Region (2004).

  23. A. Yu. Panasyuk, D. N. Isaev, G. I. Orekhova, and S. M. Pushkanskaya, “Age-related dynamics of the structure of intellectual activity in children,” in: Psychosomatic Development and Normal Responses [in Russian], Moscow (1975), pp. 56–63.

  24. L. E. Panin, “The polar metabolic type,” in: Questions of Human Ecology in the Far North [in Russian], Siberian Branch, Nauka, Novosibirsk (1979), pp. 23–32.

    Google Scholar 

  25. L. V. Poskotinova, E. V. Krivonogova, A. V. Tkachev, and L. I. Araslanova, “Latitude-related effects of autonomic reactivity in adolescents in the Arkhangel’sk Region,” Ékol. Chel., 2, No. 4, 60–62 (2004).

    Google Scholar 

  26. Zh. Zh. Rapoport, Adaptation of Children in the North [in Russian], Meditsina, Leningrad (1979).

    Google Scholar 

  27. V. P. Rozhskov, “Assessment of pathological EEG changes in children,” Detsk. Nevrol., No. 1, 47–52 (1994).

  28. N. B. Sel’verova and T. A. Filippova, “Development of systems of neuroendocrine regulation,” Physiology of Child Development [in Russian], Moscow (2000), pp. 104–127.

  29. S. I. Soroko and S. S. Bekshaev, “Statistical structure of the interaction of EEG rhythms and the individual properties of the mechanisms of brain self-regulation,” Fiziol. Zh. SSSR, 67, 1765–1773 (1981).

    PubMed  CAS  Google Scholar 

  30. S. I. Soroko, S. S. Bekshaev, and Yu. A. Sidorov, Basic Types of Brain Self-Regulatory Mechanisms [in Russian], Nauka, Leningrad (1990).

    Google Scholar 

  31. S. I. Soroko, É. A. Burykh, and G. V. Sidorenko, “Characteristics of age-related brain development in children living in the North,” Ros. Fiziol. Zh. im. I. M. Sechenova, 91, No. 7, 729–739 (2005).

    CAS  Google Scholar 

  32. S. I. Soroko, A. L. Maksimov, N. A. Agadzhanyan, I. A. Maksimova, and Yu. P. Gichev, The Multidisciplinary ‘Complex Studies in the Question of Human Ecology in Russia’ Project [in Russian], Moscow (2001).

  33. A. I. Strukov O. K. Khmel’nitskii, and V. P. Petlenko, The Morphological Equivalent of Function [in Russian], Mir, Moscow (1983).

    Google Scholar 

  34. Structural-Functional Organization of the Developing Brain [in Russian], Nauka, Leningrad (1990).

  35. A. V. Tkachev, “Effects of natural factors of the North on the human endocrine system,” in: Questions in Human Ecology [in Russian], Arkhangel’sk (2000), pp. 209–224.

  36. D. A. Farber and V. V. Alferova, The EEG in Children and Adolescents [in Russian], Pedagogika, Moscow (1972).

    Google Scholar 

  37. D. A. Farber and N. V. Dubrovinskaya, “Functional organization of the developing brain (age-related characteristics and some consistent features),” Fiziol. Cheloveka, 17, No. 5, 17–27 (1991).

    PubMed  CAS  Google Scholar 

  38. M. N. Fishman, Integrative Brain Activity in Children in Health and Disease [in Russian], Pedagogika, Moscow (1989).

    Google Scholar 

  39. T. A. Tsekhmistrenko, “Structural rearrangements of the frontal area of the cerebral cortex in children and adolescents aged 8–16 years,” in: New Studies in Age-Related Physiology [in Russian], Pedagogika, Moscow (1987), Vol. 2, No. 29, pp. 62–65.

    Google Scholar 

  40. N. S. Shumeiko, “Development of the somatosensory zone of the human cerebral cortex from birth to age 16 years,” in: New Studies in Age-Related Physiology [in Russian], Pedagogika, Moscow (1987), Vol. 2, No. 27, pp. 40–44.

    Google Scholar 

  41. N. I. Chuprikova, Psychology of Mental Development: the Principle of Differentiation [in Russian], Pedagogika, Nauka, Moscow (1997).

    Google Scholar 

  42. Yu. G. Shvartsman, S. A. Iglovskii, I. N. Bolotov, D. Yu. Polikin, R. V. Buzinov, and L. E. Savonona, “The geoecological situation in the territory of the Russian Academy of Sciences ‘Rotkovets’ geobiosphere station,” Zh. Ékol. Chel., 2, No. 4, 262–264 (2004).

    Google Scholar 

  43. L. S. Shchegoleva and L. K. Dobrodeeva, “Functional activity of immunocompetent cells (ICC) in humans in the North,” in: Questions in Human Ecology [in Russian], Northern Medical University, Arkhangel’sk (2000), pp. 267–269.

    Google Scholar 

  44. H. Ahlstrom, J. Alvero, R. Alvero, R. Espos, L. Fajutrao, J. Herrera, B. Kjellman, J. Kubista, C. Leviste, P. Meyer, G. Oldaeus, A. Siricururat, P. Vichyanond, G. Wettrell, E. Wong, L. Lazmyr, L. Nyberg, H. Olsson, E. Weibull, and J. Rosenborg, “Pharmacokinetics of bambuterol during oral administration to asthmatic children,” Brit. J. Pharmacol., 48, No. 3, 299–308 (1999).

    Article  CAS  Google Scholar 

  45. P. Andersen and S. A. Anderson, Physiological Basis of the Alpha Rhythm, Appleton-Century Crofts, New York (1968).

    Google Scholar 

  46. D. Aygun, Z. Doganay, L. Altintop, H. Guven, M. Onar, T. Deniz, and T. Sunter, “Serum acetylcholinesterase and prognosis of acute organophosphate poisoning,” J. Toxicol. Clin. Toxicol., 40, No. 7, 903–910 (2002).

    Article  PubMed  CAS  Google Scholar 

  47. C. Barta, M. Sasvari-Szekely, A. Devai, E. Kovacs, M. Staub, and P. Enyedi, “Analysis of mutations in the plasma cholinesterase gene of patients with a history of prolonged neuromuscular block during anesthesia,” Mol. Genet. Metab., 74, No. 4, 484–488 (2001).

    Article  PubMed  CAS  Google Scholar 

  48. C. F. Bartels, K. James, and B. N. La Du, “DNA mutations associated with the human butyrylcholinesterase J-variant,” Amer. J. Hum. Genet., 50, No. 5, 1104–1114 (1992).

    PubMed  CAS  Google Scholar 

  49. A. Despopoulus and S. Silbernagl, Color Atlas of Physiology, New York (1986).

  50. G. L. Ellman, K. D. Courtney, V. Andres, Jr., and R. M. Featherstone, “A new and rapid colorimetric determination of acetylcholinesterase activity,” Biochem. Pharmacol., 7, No. 1, 88–95 (1961).

    Article  PubMed  CAS  Google Scholar 

  51. R. W. Westabrook, M. Franklin, and B. Cohen, “Influence of hepatic microsomal mixed function oxidation reactions on cellular metabolic control,” Metabolism, 20, 187–199 (1971).

    Article  Google Scholar 

  52. I. D. Green and A. A. Arduini, “Hippocampal electrical activity in arousal,” J. Neurophysiol., 17, No. 6, 533–540 (1954).

    PubMed  CAS  Google Scholar 

  53. M. Matamara and K. Yamamoto, “Age development and sex differences of various EEG elements in healthy children and adults,” EEG Clin. Neurophysiol., 83, 350–357 (1992).

    Article  Google Scholar 

  54. S. C. Mitchel and R. H. Waring, “The early history of xenobiotic sulfoxidation,” Drug. Metab. Rev., 16, No. 3, 255–284 (1985).

    Google Scholar 

  55. R. S. Morison and E. W. Dempsey, “Mechanisms of thalamocortical augmentation and repetition,” Amer. J. physiol., 138, 297–302 (1943).

    Google Scholar 

  56. L. Osorio-Rico, S. Galvan-Arzate, and C. Rios, “Thallium increases monoamine oxidase activity and serotonine turnover rate in rat brain regions,” Neurotoxicol. Teratol., 17, No. 1, 1–15 (1995).

    Article  PubMed  CAS  Google Scholar 

  57. A. Poblano, S. J. Rothenberg, M. E. Fonseca, M. L. Cruz, T. Flores, and I. Zarco, “Salivatory testosterone and EEG spectra of 9 to 11-year-old male children,” Dev. Neuropsychol., 23, No. 3, 375–384 (2003).

    Article  PubMed  Google Scholar 

  58. J. C. Shih, K. Chen, and M. J. Ridd, “Monoamine oxidase: from genes to behavior,” Ann. Rev. Neurosci., 22, 197–217 (1999).

    Article  PubMed  CAS  Google Scholar 

  59. T. L. Sourkes, “Monoamine oxidase: synthesis, metabolism and function,” Med. Probl. Pharmacopsychiatry, 19, 1–14 (1983).

    CAS  Google Scholar 

  60. J. Tanner, Growth at Adolescence, Oxford (1962).

  61. R. W. Thatcher, “Cyclic cortical reorganization during early childhood,” Brain Cognit., 20, 24–36 (1992).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Interinstitute Laboratory for Comparative Ecological-Physiological Studies, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry and North-East Scientific Center, Far Eastern Branch, Russian Academy of Sciences, 44 Torez Prospekt, 194223, St. Petersburg, Russia

    S. I. Soroko, É. A. Burykh, S. S. Bekshaev, G. V. Sidorenko & E. G. Sergeeva

  2. Functional Biochemistry Laboratory, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Torez Prospekt, 194223, St. Petersburg, Russia

    A. E. Khovanskikh, B. N. Kormilitsyn, S. N. Moralev & O. V. Yagodina

  3. Department of Ecological Immunology, Institute of the Physiology of Natural Adaptation, Urals Branch, Russian Academy of Sciences, 249 Lomonosov Prospekt, 163061, Arkhangel’sk, Russia

    L. K. Dobrodeeva

  4. Medical Biophysics Laboratory, N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, 4 Kosygin Street, 117977, Moscow

    I. A. Maksimova & O. V. Protasova

Authors
  1. S. I. Soroko
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. É. A. Burykh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. S. Bekshaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. V. Sidorenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. G. Sergeeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. E. Khovanskikh
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. B. N. Kormilitsyn
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. S. N. Moralev
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. O. V. Yagodina
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. L. K. Dobrodeeva
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. I. A. Maksimova
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. O. V. Protasova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. I. Soroko.

Additional information

__________

Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 92, No. 8, pp. 905–929, August, 2006.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Soroko, S.I., Burykh, É.A., Bekshaev, S.S. et al. Characteristics of the formation of systems activity in the brain and autonomic functions in children in conditions of the European North (discussion paper). Neurosci Behav Physiol 37, 857–874 (2007). https://doi.org/10.1007/s11055-007-0093-5

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11055-007-0093-5

Key words

Search

Navigation