Journal of Nanoparticle Research

, Volume 12, Issue 5, pp 1625–1636

Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli

  • Lingling Zhang
  • Yunhong Jiang
  • Yulong Ding
  • Nikolaos Daskalakis
  • Lars Jeuken
  • Malcolm Povey
  • Alex J. O’Neill
  • David W. York
Research Paper

DOI: 10.1007/s11051-009-9711-1

Cite this article as:
Zhang, L., Jiang, Y., Ding, Y. et al. J Nanopart Res (2010) 12: 1625. doi:10.1007/s11051-009-9711-1

Abstract

Aqueous suspensions containing 4.45 × 10−5 − 1.25 × 10−3 M ZnO particles exhibit a strong antibacterial activity against E. coli under the dark conditions. The dominant mechanisms of such antibacterial behaviour are found to be either or both of chemical interactions between hydrogen peroxide and membrane proteins, and chemical interactions between other unknown chemical species generated due to the presence of ZnO particles with the lipid bilayer. The effect of direct physical interactions between nanoparticles and biological cells are found to play a relatively small role under the conditions of this study.

Keywords

ZnO nanoparticlesE. coliToxicityAntibacterialMechanismLipid vesiclesEHS

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Lingling Zhang
    • 1
  • Yunhong Jiang
    • 2
  • Yulong Ding
    • 2
  • Nikolaos Daskalakis
    • 3
  • Lars Jeuken
    • 3
  • Malcolm Povey
    • 4
  • Alex J. O’Neill
    • 5
  • David W. York
    • 6
  1. 1.School of Civil and Environmental EngineeringUniversity of Science and TechnologyBeijingChina
  2. 2.Institute of Particle Science & EngineeringUniversity of LeedsLeedsUK
  3. 3.School of Physics and AstronomyUniversity of LeedsLeedsUK
  4. 4.Procter Department of Food ScienceUniversity of LeedsLeedsUK
  5. 5.Faculty of Biological SciencesUniversity of LeedsLeedsUK
  6. 6.Procter and Gamble Newcastle Technical CentreNewcastle-upon-TyneUK