Journal of Nanoparticle Research

, Volume 11, Issue 5, pp 1219–1225

Facile method for CLSM imaging unfunctionalized Au nanoparticles through fluorescent channels

Authors

  • Lan Yuan
    • Medical and Healthy Analytical CenterPeking University Health Science Center
  • Wei Wei
    • Institute of Process EngineeringChinese Academy of Sciences
    • School of Public HealthJilin University
  • Zhiwei Sun
    • School of Public HealthJilin University
  • Hongfang Wang
    • School of Public HealthJilin University
  • Xiuzhi Zhang
    • School of Public HealthJilin University
  • Yueyue Chen
    • School of Public HealthJilin University
Technology and Applications

DOI: 10.1007/s11051-009-9618-x

Cite this article as:
Yuan, L., Wei, W., Li, J. et al. J Nanopart Res (2009) 11: 1219. doi:10.1007/s11051-009-9618-x

Abstract

The microscopic visualization of metal nanoparticles has become a useful tool for the investigation of their applications in cell labeling and the study of their bio-effects. In the current study, we have developed a facile method with confocal laser scanning microscope (CLSM) to observe unfunctionalized Au nanoparticles through fluorescent channels. The sharp reflected signal and photostable property of the metal nanoparticles makes the present method very ideal for fluorescent co-localization, real-time imaging, and further quantitative analysis.

Keywords

Au nanoparticlesCLSMReal-time imagingInstrumentationNanomedicine

Supplementary material

11051_2009_9618_MOESM1_ESM.doc (1.6 mb)
(DOC 1627 kb)

Copyright information

© Springer Science+Business Media B.V. 2009