Technology and Applications

Journal of Nanoparticle Research

, Volume 11, Issue 5, pp 1219-1225

Facile method for CLSM imaging unfunctionalized Au nanoparticles through fluorescent channels

  • Lan YuanAffiliated withMedical and Healthy Analytical Center, Peking University Health Science Center
  • , Wei WeiAffiliated withInstitute of Process Engineering, Chinese Academy of Sciences
  • , Juan LiAffiliated withSchool of Public Health, Jilin University Email author 
  • , Zhiwei SunAffiliated withSchool of Public Health, Jilin University
  • , Hongfang WangAffiliated withSchool of Public Health, Jilin University
  • , Xiuzhi ZhangAffiliated withSchool of Public Health, Jilin University
  • , Yueyue ChenAffiliated withSchool of Public Health, Jilin University

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Abstract

The microscopic visualization of metal nanoparticles has become a useful tool for the investigation of their applications in cell labeling and the study of their bio-effects. In the current study, we have developed a facile method with confocal laser scanning microscope (CLSM) to observe unfunctionalized Au nanoparticles through fluorescent channels. The sharp reflected signal and photostable property of the metal nanoparticles makes the present method very ideal for fluorescent co-localization, real-time imaging, and further quantitative analysis.

Keywords

Au nanoparticles CLSM Real-time imaging Instrumentation Nanomedicine