Research Paper

Journal of Nanoparticle Research

, Volume 12, Issue 1, pp 307-317

On the magnetic field architecture required to capture superparamagnetic nanoparticles in a microcapillary flow

  • Nicholas J. DartonAffiliated withDepartment of Chemical Engineering and Biotechnology, New Museums Site Email author 
  • , Bart HallmarkAffiliated withDepartment of Chemical Engineering and Biotechnology, New Museums Site
  • , Pulkit AgrawalAffiliated withDepartment of Chemical Engineering and Biotechnology, New Museums Site
  • , Tom JamesAffiliated withDepartment of Chemical Engineering and Biotechnology, New Museums Site
  • , Vincent H. B. HoAffiliated withDepartment of Chemical Engineering and Biotechnology, New Museums Site
  • , Nigel K. H. SlaterAffiliated withDepartment of Chemical Engineering and Biotechnology, New Museums Site

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Abstract

The magnetic field required for the capture of superparamagnetic nanoparticles flowing in a microcapillary array under a constant pressure regime was investigated in vitro. It was found that the nanoparticles were captured in locations that varied significantly in magnetic field strength, and that the location of capture was strongly related to the net volumetric flow through the microcapillary array. A hypothesis is presented to explain these data in which the magnetic field of the trapping Neodymium Iron Boron (NdFeB) block magnet is divided into two zones that act differently on the nanoparticles. In the first ‘steering zone’, nanoparticles are moved closer to the capillary wall where they can be captured downstream in the second ‘capture zone’. This hypothesis can be used in the future to design magnetic field shapes for more effective particle capture at higher flow rates with lower field strengths.

Keywords

Superparamagnetic nanoparticles Microcapillary flow In-flow capture Magnetic field optimisation Nanobiotechnology Nanomedicine